目的 探討注射用丹參多酚酸對(duì)老年腦梗死患者炎性因子和預(yù)后的影響。方法 選取2017年10月—2018年4月在許昌市中心醫(yī)院神經(jīng)科住院的302例腦梗死患者作為研究對(duì)象，根據(jù)隨機(jī)數(shù)字表法分為觀察組（149例）和對(duì)照組（153例）。對(duì)照組患者給予常規(guī)腦梗死二級(jí)預(yù)防治療，觀察組患者在對(duì)照組基礎(chǔ)上靜脈滴注注射用丹參多酚酸，100 mg用0.9%氯化鈉注射液250 mL稀釋，1次/d，連續(xù)用藥14 d。治療后，比較兩組治療前后血清白細(xì)胞介素-6（IL-6）、超敏C反應(yīng)蛋白（hs-CRP）水平，采用改良Rankin量表（MRs）評(píng)估兩組預(yù)后情況。隨訪6個(gè)月，比較兩組不良事件發(fā)生率及藥品不良反應(yīng)發(fā)生情況。結(jié)果 治療后，兩組患者IL-6、hs-CRP水平均顯著低于治療前（P<0.05），且觀察組IL-6、hs-CRP水平顯著低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組預(yù)后良好率為77.1%，顯著高于對(duì)照組的62.4%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組不良事件總發(fā)生率及藥品不良反應(yīng)總發(fā)生率差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 注射用丹參多酚酸能夠顯著降低老年腦梗死患者的炎性因子水平，且能顯著改善患者預(yù)后，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the effect of Salvianolate for injection on inflammatory factors and prognosis in elderly patients with cerebral infarction. Methods Elderly patients (302 cases) with cerebral infarction in the Xuchang Central Hospital from October 2017 to April 2018 were randomly divided into observation group (149 case ) and control group (153 cases). Patients in the control group were given secondary conventional prevention and treatment of cerebral infarction, while patients in the observation group were iv administered with Salvianolate for injection on the basis of control group, 100 mg diluted with 250 mL 0.9% sodium chloride injection, once daily, and patients were treated for 14 d. After treatment, the serum levels of IL-6 and hs-CRP were compared between two groups before and after treatment. The prognosis of two groups was evaluated by modified Rankin scale (MRs). Follow-up for 6 months, the incidence of adverse events and adverse drug reactions were compared between two groups. Results The levels of IL-6 and hs-CRP in two groups after treatment were significantly lower than those before treatment (P < 0.05), and the levels of IL-6 and hs-CRP in the observation group were significantly lower than those in the control group, the difference was statistically significant (P < 0.05). The good prognosis rate in the observation group was 77.1%, which was significantly higher than 62.4% in the control group, the difference was statistically significant (P < 0.05). The total incidence of adverse events and adverse drug reactions in two groups were no significant difference. Conclusion Salvianolate for injection can significantly reduce the level of inflammatory factors in elderly patients with cerebral infarction, and can significantly improve the prognosis of patients, it has certain clinical promotion and application value.

R969.4

河南省醫(yī)學(xué)科技攻關(guān)項(xiàng)目（201602372）