目的 觀察注射用丹參多酚酸對(duì)急性腦梗死患者美國國立衛(wèi)生研究院卒中量表（NIHSS）、日常生活活動(dòng)能力（ADL）評(píng)分和血清神經(jīng)元特異性烯醇化酶（NSE）、谷胱甘肽-S-轉(zhuǎn)移酶（GST）的影響。方法 選取2016年1月1日—2017年7月1日南陽醫(yī)專第一附屬醫(yī)院神經(jīng)內(nèi)科住院的急性腦梗死患者100例為研究對(duì)象，按照隨機(jī)數(shù)字表法將患者隨機(jī)分為對(duì)照組和觀察組，每組50例。對(duì)照組患者在入院后常規(guī)治療，觀察組患者在對(duì)照組治療的基礎(chǔ)上靜脈滴注射用丹參多酚酸，100 mg加入0.9%氯化鈉液250 mL靜脈滴注，1次/d，連續(xù)14 d。分別兩組患者NIHSS、ADL評(píng)分及GST、NSE水平進(jìn)行測(cè)定。結(jié)果 兩組患者在治療后14 d NIHSS評(píng)分ADL評(píng)分均較治療前明顯改善，差別具有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后14 d，與對(duì)照組相比，觀察組患者NIHSS評(píng)分明顯下降，ADL評(píng)分明顯升高，差別具有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組患者在治療后14 d，GST、NSE水平均較治療前明顯改善，差別具有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后14 d，與對(duì)照組患者相比，觀察組GST及NSE水平改善情況更明顯，差別具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 注射用丹參多酚酸能明顯提高急性腦梗死患者血清GST水平，降低NSE水平，改善患者ADL、NIHSS評(píng)分。

Objective To observe the effect of Salvianolate for injection on NIHSS, ADL scores, and serum NSE and GST in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction admitted to the department of neurology, the First affiliated Hospital of Nanyang Medical College from January 1, 2016 to July 1, 2017 were selected. Patients were randomly divided into control group and observation group according to the random number table method, with 50 cases in each group. Patients in the control group received routine treatment after admission, and patients in the observation group received intravenous infusion of Salvianolate for injection on the basis of control group, 100 mg was added with 0.9% sodium chloride solution 250 mL, once daily for 14 consecutive days. And the NIHSS, ADL scores, and the levels of GST and NSE were measured in two groups. Results After treatment of 14 d, NIHSS score and ADL score in two groups were significantly improved (P < 0.05). After treatment of 14 d, compared with control group, the NIHSS score in the observation group were significantly decreased, and the ADL score were significantly increased, with statistically significant difference (P < 0.05). After treatment of 14 d, the levels of GST and NSE in two groups were significantly improved, with statistically significant differences (P < 0.05). After treatment of 14 d, compared with the control group, GST and NSE levels in the observation group improved more significantly, with statistically significant differences (P < 0.05). Conclusion Salvianolate for injection can significantly improve the levels of serum GST, reduce the level of NSE, and improve the ADL and NIHSS scores of patients with acute cerebral infarction.

R969.4