目的 探討多西他賽化療所致過敏反應(yīng)和體液潴留與地塞米松給藥劑量和給藥方案之間的關(guān)系，以期為臨床提供一定參考。方法 對(duì)重慶醫(yī)科大學(xué)附屬第三醫(yī)院2016年5月—2019年2月因多西他賽化療所致的過敏反應(yīng)和體液潴留進(jìn)行回顧性分析，總結(jié)過敏反應(yīng)和體液潴留臨床特點(diǎn)、相關(guān)因素、治療措施及轉(zhuǎn)歸。結(jié)果 共搜集247例使用多西他賽化療患者，發(fā)生過敏反應(yīng)和體液潴留患者分別為11例（4.45%）和10例（4.05%），其中過敏反應(yīng)與患者是否存在過敏史具有統(tǒng)計(jì)意義（P<0.05），過敏反應(yīng)發(fā)生率隨地塞米松劑量增大而降低，但無統(tǒng)計(jì)意義；體液潴留的發(fā)生與地塞米松給藥劑量和給藥方案相關(guān)（P<0.05），低劑量地塞米松預(yù)處理時(shí)發(fā)生率最低。結(jié)論 針對(duì)多西他賽化療所致過敏反應(yīng)和體液潴留，應(yīng)給予有效預(yù)處理，降低發(fā)生率，提高患者耐受性。

Objective To explore the relationship between the allergic reaction and fluid retention induced by docetaxel chemotherapy, and dexamethasone dose and regimen, in order to provide some reference for clinical practice. Methods A retrospective analysis of allergic reaction and fluid retention caused by docetaxel from May 2016 to February 2019 in the Third Affiliated Hospital of CQMU was conducted, in order to summarize the clinical features, related factors, treatment measures and outcomes of allergic reaction and fluid retention. Results A total of 247 patients were treated with docetaxel. Allergic reaction and fluid retention occurred in 4.45% and 4.05% of patients, respectively. There is significant difference between allergic reaction and allergic history (P < 0.05). The incidence of allergic reaction decreased with increasing dose of dexamethasone, but it was not statistically significant. The incidence of fluid retention was not only related to the dose of dexamethasone, but also the administration schedule (P < 0.05). The incidence of fluid retention decreased with decreasing dose of dexamethasone. Conclusion For the allergic reaction and fluid retention caused by docetaxel chemotherapy, effective pretreatment should be given to reduce the incidence and improve patient tolerance.

R979.1