目的 觀察蓽鈴胃痛顆粒聯(lián)合莫沙必利治療老年功能性消化不良餐后不適綜合征患者的臨床療效。方法 選取2017年4月-2019年10月在皖南醫(yī)學院第二附屬醫(yī)院就診的功能性消化不良餐后不適綜合征患者106例，按隨機數(shù)字表法分為組對照和觀察組，每組各53例。對照組患者于餐前30 min口服枸櫞酸莫沙必利片，5 mg/次，3次/d。觀察組在對照組治療基礎(chǔ)上給予蓽鈴胃痛顆粒，餐前30 min開水沖服，5 g/次，3次/d。兩組連續(xù)治療1周。比較兩組餐后不適綜合征臨床癥狀評分、臨床療效、血清胃泌素（G-17）、胃蛋白酶原（PG）I、PGII水平和不良反應情況。結(jié)果 治療后，兩組患者治療后餐后飽脹不適、上腹脹、早飽、噯氣、胃納減少評分明顯減少（P<0.01）；治療后，觀察組患者的餐后飽脹不適、上腹脹、早飽、噯氣、胃納減少評分顯著低于對照組（P<0.01）。治療后，觀察組總有效率為94.34%，對照組總有效率為77.36%，兩組比較差異有統(tǒng)計學意義（P<0.05）。兩組患者治療后血清G-17水平明顯減少，血清PGI、PGII水平顯著增加（P<0.01）；治療后，觀察組患者的血清G-17水平顯著低于對照組，PGI、PGII明顯高于對照組（P<0.01）。兩組均無嚴重不良反應。結(jié)論 蓽鈴胃痛顆粒聯(lián)合莫沙必利可有效改善老年功能性消化不良餐后不適綜合征患者的癥狀體征和胃排空功能，提高臨床療效，且安全性較好。

Objective To observe the efficacy of Biling Weitong Granules combined with mosapride in treatment of elderly patients with postprandial distress syndrome of functional dyspepsia. Methods A total of 106 patients with postprandial distress syndrome of functional dyspepsia in the Second Affiliated Hospital of Wannan Medical College from April 2017 to October 2019 were selected and divided into control group and observation group according to the random number table method, with 53 cases in each group. Patients in the control group were po administered with Mosapride Citrate Tablets 30 min before meals, 5 mg/time, three times daily. Patients in the observation group were po administered with Biling Weitong Granules on the basis of control group, which were taken by boiling water 30 min before the meals, 5 g/time, three times daily. Patients in two groups were treated for 1 week. The clinical symptom scores, clinical efficacy, serum G-17, PG I, PG II levels, and adverse reactions in two groups were compared. Results After treatment, the scores of postprandial satiety and discomfort, upper abdominal distension, early satiety, belching, and gastric absorption reduction in two groups were significantly decreased (P<0.01). After treatment, the score of postprandial satiety and discomfort, upper abdominal distension, early satiety, belching, and gastric absorption reduction in the observation group was significantly lower than those in the control group (P<0.01). After treatment, the total effective rate was 94.34% in the observation group, and 77.36% in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the serum levels of G-17 in two groups were significantly decreased, but the PG I and PG II levels were increased (P<0.01), and the level of G-17 in the observation group was significantly lower than those in the control group, the levels of PG I and PG II were significantly higher than those in the control group (P<0.01). There were no serious adverse reactions in two groups. Conclusion BilingWeitongGranulescombinedwithmosapridecaneffectivelyimprovethesymptomsandsigns,gastricemptyingfunction of elderly patients with postprandial distress syndrome of functional dyspepsia, and improve the clinical efficacy, with good safety.

R975

國家自然科學基金青年科學基金項目（81800445）