[關(guān)鍵詞]
[摘要]
目的 探討健脾生血顆粒治療兒童缺鐵性貧血的臨床療效。方法 選取2014年5月-2019年7月河北北方學(xué)院附屬第一醫(yī)院門診收治的缺鐵性貧血患兒106例為研究對(duì)象,隨機(jī)將患兒分為觀察組和對(duì)照組,每組各53例。對(duì)照組患兒口服琥珀酸亞鐵片,1片/次,2次/d。觀察組口服健脾生血顆粒,0.75 g/kg,每天分3次于飯后服用。兩組患者均連續(xù)服用4周。觀察兩組患兒的臨床療效,比較兩組血清學(xué)指標(biāo)、生長(zhǎng)發(fā)育指標(biāo)和不良反應(yīng)發(fā)生率。結(jié)果 治療后,觀察組總有效率為90.57%,明顯高于對(duì)照組的75.47%,兩組間比較差異顯著(P<0.05)。治療后,兩組血紅蛋白(Hb)、血清鐵蛋白(SF)、平均紅細(xì)胞體積(MCV)、平均紅細(xì)胞血紅蛋白(MCH)水平顯著升高(P<0.05),且觀察組患者的Hb、SF、MCV、MCH水平均高于對(duì)照組(P<0.05)。治療后,兩組患兒智力發(fā)育指數(shù)(MDI)、精神運(yùn)動(dòng)發(fā)育指數(shù)(PDI)、精神運(yùn)動(dòng)發(fā)育商(DQ)評(píng)分均顯著升高(P<0.05);且觀察組患兒的貝利量表評(píng)分均高于對(duì)照組(P<0.05)。治療期間,兩組不良反應(yīng)發(fā)生率比較差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 健脾生血顆粒治療患兒缺鐵性貧血的療效較好,能夠升高患兒機(jī)體Hb、SF、MCV、MCH等指標(biāo)水平,改善患兒的發(fā)育狀態(tài),且治療安全性良好,值得臨床推薦。
[Key word]
[Abstract]
Objective To study the clinical effect of Jianpi Shengxue Granules in treatment of iron deficiency anemia in children. Methods Children (106 cases) with iron deficiency anemia in the First Affiliated Hospital of Hebei North University from May 2014 to July 2019 were randomly divided into observation group and control group, 53 cases in each group. Children in the control group were po administered with Ferrous Succinate Tablets, 1 tablet/time, twice daily. Children in the observation group were po administered with Jianpi Shengxue Granules, 0.75 g/kg, taken it three times after meals. Patients in two groups were treated continuously for 4 weeks. The clinical efficacy in two groups was observed, the serological indexes, growth and development indexes, and the incidence of adverse reactions were compared between two groups. Results After treatment, the total effective rate in the observation group was 90.57%, which was higher than 75.47% in the control group (P<0.05). After treatment, the levels of Hb, SF, MCV, and MCH in two groups were significantly increased (P<0.05), and the Hb, SF, MCV, and MCH levels in the observation group were higher than those in the control group (P<0.05). After treatment, the scores of MDI, PDI, and DQ in two groups were significantly increased (P<0.05), and the Bailey scale in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between two groups during treatment. Conclusion The therapeutic effect of Jianpi Shengxue Granules in treatment of children with iron deficiency anemia is good, which can increase the levels of Hb, SF, MCV, and MCH of children, and improve the development of children, the treatment safety is good, it is worthy of clinical recommendation.
[中圖分類號(hào)]
R973
[基金項(xiàng)目]