目的 探討骨炎靈片對急性骨髓炎患者的臨床療效及血清炎性指標的影響。方法 選取2018年1月-2019年6月于南陽市第二人民醫(yī)院106例急性骨髓炎患者作為研究對象，將所有患者隨機分為對照組和觀察組，每組各53例。對照組給予行骨開窗減壓和持續(xù)負壓引流術等外科處理，同時給予敏感抗生素靜脈滴注，注意補充水和電解質等綜合治療。觀察組在對照組治療基礎上口服骨炎靈片，2.4 g/次，4次/d。兩組療程均為1個月。比較兩組患者的臨床療效、創(chuàng)面愈合時間、住院時間、疼痛緩解50%時間及外周血白細胞（WBC）、中性粒細胞（N）、超敏C反應蛋白（hs-CRP）及血沉（ESR）水平的差異。結果 治療后，對照組和觀察組總有效率分別為81.13%和94.34%，差異具有統(tǒng)計學意義（P<0.05）。治療后，觀察組在創(chuàng)面愈合時間、住院時間和VAS評分降低50%時間均明顯低于對照組，兩組比較差異均具有統(tǒng)計學意義（P<0.05）。治療后，兩組患者外周血WBC、N、hs-CRP和ESR水平均顯著降低，差異均具有統(tǒng)計學意義（P<0.05）；與對照組相比，觀察組外周血WBC、N、hs-CRP和ESR水平顯著降低，差異均具有統(tǒng)計學意義（P<0.05）。結論 骨炎靈片治療急性骨髓炎具有較好的臨床療效，能促進創(chuàng)面愈合，顯著緩解機體疼痛和降低炎癥指標，值得在臨床中推廣使用。

Objective To investigate the clinical efficacy and serum inflammatory factors levels of Guyanling Tablets in treatment of acute osteomyelitis.Methods A total of 106 patients with acute osteomyelitis in Second People's Hospital from January 2018 to June 2019 were selected. All the patients were randomly divided into control group and observation group, 53 cases in each group. The control group was given surgical treatment, such as decompression through bone fenestration and continuous negative pressure drainage, as well as intravenous infusion of sensitive antibiotics and comprehensive treatment including water and electrolyte supplementation. Patiens in the observation group were po administered with Guyanling Tablets on the basis of control group, 2.4 g/time, four times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy, wound healing time, hospital stay, VAS scores decreased 50% time, and the serum levels of WBC, neutrophil, hs-CRP, and ESR were compared.Results After treatment, the total effective rate in the control group and observation group were 81.13% and 94.34%, respectively, the difference is statistically significant (P<0.05). After treatment, the wound healing time, hospital stay, and VAS scores decreased 50% time in the observation group was significantly lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, WBC, N, hs-CRP, and ESR levels in peripheral blood of the two groups were significantly decreased, with statistically significant differences (P<0.05). After treatment, WBC, N, hs-CRP, and ESR levels in the peripheral blood of the observation group were significantly lower than those in the control group, with statistically significant differences (P<0.05). Conclusions Guyanling Tablets has a good clinical effect in treatment of acute osteomyelitis, can promote wound healing, significantly relieve body pain and reduce the inflammatory indicators, and is worthy of promotion in clinical use.

R287.2