目的 系統(tǒng)評價(jià)利多卡因治療耳鳴的療效，為老藥新用提供臨床依據(jù)。方法 計(jì)算機(jī)檢索Pubmed、Embase、Cochrane Central、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫（CBM）、中國學(xué)術(shù)期刊全文數(shù)據(jù)庫（CNKI）、維普中文期刊全文數(shù)據(jù)庫（VIP）和萬方數(shù)據(jù)庫中利多卡因治療主觀性耳鳴的臨床隨機(jī)對照試驗(yàn)（RCTs），檢索時(shí)間從建庫到2019年6月，采用Review Manager 5.3軟件進(jìn)行數(shù)據(jù)分析。結(jié)果 共歸入17篇RCTs，1 691位患者（1 737耳），其中對照組842例，試驗(yàn)組859例。Meta-分析結(jié)果顯示利多卡因?qū)ΧQ的療效高于傳統(tǒng)療法（OR=3.11，95% CI=2.44~3.97，Z=9.12，P<0.000 01）。結(jié)論 利多卡因能明顯緩解耳鳴癥狀，具有較高的臨床應(yīng)用價(jià)值。

Objective In order to provide clinical evidence for the new role of old drugs, systematically evaluate the curative effect of lidocaine on tinnitus. Methods The clinical randomized controlled trials (RCTs) about lidocaine in treatment of subjective tinnitus in Pubmed, Embase, Cochrane Central, CNKI, CBM, VIP and Wanfang database were searched until June 2019 by computer. Data statistics were conducted by Review Manager 5.3 software. Results A total of 17 RCTs articles and 1 691 patients (1 737 ears) were included. The control group includes 842 cases and the experimental group is 859 cases. Meta-analysis result shows that lidocaine has a higher therapeutic effect on tinnitus than traditional therapies (95%CI=2.44~3.97, OR=3.11, Z=9.12, P<0.000 01). Conclusion Lidocaine can significantly relieve the symptoms of tinnitus in patients and has a strong clinical application value.

R987

山東省醫(yī)藥衛(wèi)生科技發(fā)展計(jì)劃保健項(xiàng)目（2015BJYB44）