活性蛋白質(zhì)組技術(shù)（ABPP）是越來(lái)越多的化學(xué)蛋白質(zhì)組學(xué)方法之一，該技術(shù)利用小分子化學(xué)探針來(lái)探索化合物和靶點(diǎn)之間的相互作用機(jī)制。在中藥活性成分分子靶點(diǎn)的鑒定中，ABPP技術(shù)具有高效、準(zhǔn)確等優(yōu)越性，目前已經(jīng)利用該技術(shù)鑒定了許多中藥活性成分的分子靶點(diǎn)。綜述了ABPP技術(shù)在中藥活性分子靶點(diǎn)中的應(yīng)用，包括青蒿素、黃芩苷、穿心蓮內(nèi)酯、蘇木酮、龍牙蔥木皂苷、山楂酸、蟾毒內(nèi)酯、毛蘭素與蓽茇寧等，為創(chuàng)新藥物靶點(diǎn)的發(fā)現(xiàn)提供新的思路。

The activity-based proteome technique (ABPP) is one of the growing number of chemical proteomics methods that exploit small molecular chemical probes to explore the mechanisms of interaction between compounds and targets. The technology has been used to identify many molecular targets of active components of traditional Chinese medicine. The application of ABP technology in the molecular targets of active components of traditional Chinese medicine, including artemisinin, baicalin, andrographolide, hematoxylone, scallion saponins, hawthorn acid, toadlactone, maulanin and piper longone were reviewed, in order to provide new ideas for the development of traditional Chinese medicine and the discovery of innovative drug targets.

R965.2

國(guó)家科技重大專(zhuān)項(xiàng)（2015ZX09501004-001-003）