(0-t)、Cmax隨給藥劑量的增加而增大;連續(xù)iv給藥,低、中、高劑量組動(dòng)物血藥濃度、AUC(0-t)、Cmax在給藥第1、29、71天時(shí)均變化不大,無(wú)明顯蓄積傾向。而注射用長(zhǎng)春瑞濱膠連續(xù)iv給藥后隨給藥時(shí)間延長(zhǎng),動(dòng)物血藥濃度、AUC(0-t)、Cmax有上升趨勢(shì),AUC(0-t)蓄積因子分別為2.08、1.80,Cmax蓄積因子分別為2.58、2.32,均有蓄積傾向。結(jié)論 注射用酒石酸長(zhǎng)春瑞濱膠束與普通注射用酒石酸長(zhǎng)春瑞濱毒動(dòng)學(xué)參數(shù)比較,無(wú)明顯的蓄積傾向,可降低長(zhǎng)期服藥的毒性風(fēng)險(xiǎn)。;Objective To establish a quick method to analyze vinorelbine tartrate in plasma of beagle dogs and compare the toxicokinetics of vinorelbine tartrate micelle for injection and vinorelbine tartrate for injection. Methods Sixteen beagle dogs were selected and divided into four groups, who received multiple dose of 0.29, 0.58 and 1.174 mg/kg vinorelbine tartrate micelle for injection and 1.174 mg/kg vinorelbine tartrate for injection respectively. The plasma concentrations of vinorelbine tartrate micelle were determined by LC-MS/MS. Using DAS3.1.4 pharmacokinetic software to calculate the kinetic parameters. Results The blood concentration, AUC(0-t) and Cmax of beagle dogs increased with the increase of iv dose. The blood concentration, AUC(0-t) and Cmax of beagle dogs in the low, middle and high dose groups did not change significantly at the 1st, 29th and 71st day of administration. After iv continuous administration of vinorelbine for injection, the concentration of blood drug, AUC(0-t), Cmax increased with the increase of administration time. The accumulation factors of AUC(0-t) were 2.08, 1.80, and Cmax were 2.58 and 2.32, respectively. Conclusion Compared with the pharmacokinetic parameters of vinorelbine tartrate for injection, vinorelbine tartrate for injection has no obvious accumulation tendency, which can reduce the risk of long-term toxicity."/>