氧化苦參堿能抑制人胃癌MGC-803細(xì)胞移植瘤或人胰腺癌BxPC-3細(xì)胞移植瘤在裸鼠體內(nèi)生長。體外實驗發(fā)現(xiàn)氧化苦參堿能濃度相關(guān)地抑制人胃癌SGC-7901細(xì)胞、MGC803細(xì)胞、BGC823細(xì)胞、MKN-45細(xì)胞，人胰腺癌SW1990細(xì)胞，人食管癌Eca-109細(xì)胞增殖并誘導(dǎo)凋亡。體外實驗發(fā)現(xiàn)氧化苦參堿能增強化療藥抗人胃癌SGC-7901細(xì)胞作用。臨床上已試用于食管癌的治療。

Oxymatrine inhibits the growth of transplantation tumor of human gastric carcinoma MGC-803 cells, or human pancreatic cancer BxPC-3 cells in nude mice. Oxymatrine inhibits proliferation and induces apoptosis in association with dosage on human gastric carcinoma SGC-7901 cells, MGC803 cells, BGC823 cells, MKN-45 cells, and human pancreatic cancer SW1990 cells, and human carcinoma of esophagus Eca109 cells, in vitro. Oxymatrine can promote the effects of chemotherapeutics against gastric carcinoma SGC-7901 cells in vitro. In clinic oxymatrine has been tried on the treatment of carcinoma of esophagus.

R285.5;R287.6