病毒感染性疾病致病率高、傳染性強(qiáng)、危害性大，對人類健康乃至社會發(fā)展造成很大威脅，因此尋找預(yù)防及治療藥物一直是關(guān)注的重點(diǎn)。氯喹、羥基氯喹是美國食品藥品管理局批準(zhǔn)的治療瘧疾、風(fēng)濕免疫病的常用藥，藥品的成本低、安全性高?；仡櫫硕囗?xiàng)氯喹、羥氯喹抗病毒的藥理研究及臨床試驗(yàn)，歸納了二者對于人冠狀病毒（HCoVs）、人免疫缺陷病毒（HIV）、寨卡病毒、腸道病毒71型（EV-A71）、朊病毒等多類病毒的作用，其具有廣譜抗病毒作用，在臨床上有較好的應(yīng)用前景。

Viral infectious disease have the characteristics of high pathogenicity, strong infectivity and great damage, which pose great threats to human health, and even to social development and stability. Therefore, discovering preventive and therapeutic drugs has always been the focus of society. Chloroquine and hydroxychloroquine are common drugs approved by the US Food and Drug Administration for the treatment of malaria and rheumatic immune disease, with low-budget as well as high safety. This review analyzed studies about the antiviral activity of chloroquine and hydroxychloroquine, including laboratory experiments and clinical trials about human coronavirus, HIV, Zika virus, and enterovirus E-7. The effects of many types of viruses suggestted that chloroquine and hydroxychloroquine possess great clinical application potential.

R978.7