目的 探討丹紅注射液聯(lián)合磺達肝癸鈉對肺栓塞患者免疫學指標及凝血-纖溶系統(tǒng)的影響。方法 選擇2014年8月—2018年8月在喀什地區(qū)第二人民醫(yī)院確診的80例肺栓塞患者作為研究對象。隨機將患者分為對照組和觀察組，每組各40例。對照組患者皮下注射磺達肝癸鈉注射液，2.5 mg/次，1次/d，第4天起聯(lián)合應用華法林抗凝5 d，并通過監(jiān)測國際標準化比值（INR）來調(diào)整華法林用量，之后停用磺達肝癸鈉并持續(xù)應用華法林抗凝。觀察組在對照組治療的基礎上靜脈滴注丹紅注射液，將20 mL丹紅注射液加入到氯化鈉溶液250 mL中，1次/d。兩組均連續(xù)治療2周。觀察兩組患者的臨床療效，同時比較兩組治療前后的免疫學指標、凝血-纖溶系統(tǒng)指標水平。結(jié)果 治療后，觀察組總有效率為90.00%，顯著高于對照組的72.50%（P<0.05）。與治療前相比，兩組各免疫學指標均明顯改善（P<0.05），且觀察組優(yōu)于對照組（P<0.05）。治療后，兩組D-二聚體（D-D）、纖維蛋白原降解產(chǎn)物（FDP）、纖溶酶原激活物抑制劑（PAI-I）與組織型纖溶酶原激活物（tPA）活性均顯著降低，凝血酶原時間（PT）與血小板計數(shù)（PLT）水平顯著升高（P<0.05），且觀察組凝血-纖溶系統(tǒng)指標水平顯著優(yōu)于對照組（P<0.05）。結(jié)論 丹紅注射液聯(lián)合磺達肝癸鈉可有效改善患者的免疫功能及凝血-纖溶系統(tǒng)，療效安全顯著，對促進肺栓塞患者病情康復具有積極意義。

Objective To explore the effect of Danhong Injection combined with fondaparinux sodium on immunological indicators and coagulation-fibrinolysis system in patients with pulmonary embolism. Methods Patients (80 cases) with pulmonary embolism in the Second People's Hospital of Kashgar from August 2014 to August 2018 were selected as the study subjects. Patients were randomly divided into control group and observation group, with 40 patients in each group. Patients in the control group were subcutaneously injected with Fondaparinux Sodium Injection, 2.5 mg/time, once daily, combined with warfarin anticoagulation for 5 days from the 4th day, and the dosage of warfarin was adjusted by monitoring the INR. After that, Fondaparinux Sodium Injection was stopped and warfarin anticoagulation was continued. Patients in the observation group were iv administered with Danhong Injection on the basis of control group, and 20 mL Danhong Injection was added to 250 mL sodium chloride solution, once daily. Both groups were treated continuously for 2 weeks. The clinical efficacy in two groups was observed, and the indexes of immunology and coagulation-fibrinolysis system were compared before and after treatment. Results After treatment, the total effective rate in the observation group was 90.00%, which was significantly higher than 72.50% in the control group (P<0.05).Compared with before treatment, the immunological indexes in two groups were significantly improved (P<0.05), and the indexes in the observation group was better than those in control group (P<0.05). Compared with before treatment, the levels of D-D, FDP, PAI-I, and tPA in two groups were significantly decreased after treatment, and the levels of PT and PLT were significantly increased (P<0.05). Moreover, the indicators of coagulation and fibrinolysis in the observation group were significantly better than those in the control group (P<0.05). Conclusion Danhong Injection combined with fondaparinux sodium can effectively improve the immune function and the coagulation and fibrinolysis system of patients, with a safe and significant effect, and has positive significance in promoting the rehabilitation of patients with pulmonary embolism.

R974

新疆維吾爾自治區(qū)自然科學基金項目（2016D01C092）；喀什地區(qū)科學研究與技術(shù)開發(fā)計劃項目（KS2018017）