中藥復(fù)方作為中醫(yī)臨床用藥最廣泛的形式，其藥效物質(zhì)基礎(chǔ)和作用機(jī)制的科學(xué)闡釋成為全面揭示中醫(yī)藥實(shí)用價(jià)值進(jìn)而實(shí)現(xiàn)中藥現(xiàn)代化的關(guān)鍵。代謝組學(xué)技術(shù)始于20世紀(jì)90年代中期，旨在利用現(xiàn)代科學(xué)技術(shù)研究生物體系在受到刺激或干擾后，內(nèi)源性代謝物組的變化或隨時(shí)間的變化規(guī)律，以代謝物組分析為基礎(chǔ)，借助高通量檢測和多元化數(shù)據(jù)處理手段，整合多維生物信息系統(tǒng)，闡明中藥復(fù)方的藥效物質(zhì)基礎(chǔ)和作用機(jī)制。綜述了最新代謝組學(xué)技術(shù)的研究進(jìn)展及在中藥復(fù)方藥效物質(zhì)基礎(chǔ)和作用機(jī)制研究中的應(yīng)用情況，并對代謝組學(xué)技術(shù)未來發(fā)展趨勢進(jìn)行展望。

Traditional Chinese medicine(TCM) prescriptions is the most extensive form in clinical parctice for traditional Chinese medicine, and its effective substances and mechanism is key to achieve modernization and comprehensively reveal the essence of traditional Chinese medicine theory. Metabolomics began in the mid-1990s with the aim of using modern science and technology to probe into the endogenous metabolites changes and time-dependent discipline after stimulation or interference in biological systems. It clarifies effective substances and mechanism based on metabolite analysis, high-throughput detection, diversity data processing andsystematic information integration. In this paper, we reviewed metabolomics technology development in recent years and its application in effective substances and mechanism of TCM prescriptions research. Meanwhile, modernization research and the future trend were also discussed.

國家重大科技專項(xiàng)重大新藥創(chuàng)制——中醫(yī)藥優(yōu)勢領(lǐng)域的創(chuàng)新中藥關(guān)鍵技術(shù)開發(fā)研究（2017ZX09301005