近年來(lái)圍繞注射用丹參多酚酸（SAFI）及其水溶酚酸類成分在卒中后抑郁及卒中后意識(shí)障礙中的腦保護(hù)作用開(kāi)展了大量藥理作用及藥理機(jī)制的研究。從抗炎、抗氧化、抗細(xì)胞凋亡3個(gè)方面，對(duì)SAFI及其酚酸類成分（包括丹酚酸B、迷迭香酸、丹酚酸C、丹參素、原兒茶酸）在卒中后抑郁和卒中后意識(shí)障礙中的腦保護(hù)作用及其機(jī)制進(jìn)行總結(jié)，以期為SAFI在臨床上優(yōu)化卒中康復(fù)治療方案提供理論依據(jù)。

In recent years, numerous pharmacological and mechanism studies have been conducted on the cerebral protection of Salvianolic Acids for Injection (SAFI) and its aqueous depsides in post-stroke depression (PSD) and post-stroke cognitive impairment (PSCI). This article summarized the cerebral protective mechanisms of SAFI and its aqueous depsides (including salvianolic acid B, rosmarinic acid, salvianolic acid C, danshensu and protocatechuic acid) in PSD and PSCI from the aspects of anti-inflammatory, anti -oxidant and anti -apoptosis, to provide theoretical basis for clinical application of SAFI and optimizing rehabilitation programs of stroke.

R285.6;R286.1

天津市科技重大專項(xiàng)與工程（18ZXXYSY00120）