目的 探討注射用丹參多酚酸聯(lián)合阿托伐他汀治療急性腦梗死的臨床療效，及對(duì)氧化型低密度脂蛋白（ox-LDL）和心型脂肪酸結(jié)合蛋白（H-FABP）影響。方法 選擇2017年6月-2018年12月鶴壁煤業(yè)（集團(tuán)）有限責(zé)任公司總醫(yī)院收治的腦梗塞急性期患者86例作為研究對(duì)象，采用隨機(jī)數(shù)字表法隨機(jī)分為對(duì)照組（n=43）和觀察組（n=43）。對(duì)照組口服阿托伐他汀鈣片，20 mg/次，1次/d。觀察組在對(duì)照組治療的基礎(chǔ)上靜脈滴注注射用丹參多酚酸，100 mg加入250 mL生理鹽水中，1次/d。兩組療程均為14 d。觀察兩組患者的臨床療效，同時(shí)比較兩組患者治療前后的凝血功能、炎癥介質(zhì)、ox-LDL和H-FABP水平。結(jié)果 治療后，觀察組總有效率為93.02%，顯著高于對(duì)照組的72.09%（P<0.05）。治療后，兩組患者纖維蛋白原（Fib）和D-二聚體指標(biāo)均顯著降低（P<0.05）；治療后，觀察組患者Fib和D-二聚體指標(biāo)低于對(duì)照組（P<0.05）。治療后，兩組白細(xì)胞介素-18（IL-18）、腫瘤壞死因子-α（TNF-α）和基質(zhì)金屬蛋白酶-9（MMP-9）水平均顯著降低（P<0.05）；治療后，觀察組患者IL-18、TNF-α和MMP-9水平顯著低于對(duì)照組（P<0.05）。治療后，兩組患者ox-LDL和HFABP水平均顯著降低（P<0.05）；治療后，觀察組患者ox-LDL和H-FABP水平顯著低于對(duì)照組（P<0.05）。結(jié)論 注射用丹參多酚酸聯(lián)合阿托伐他汀治療急性腦梗死患者的療效明顯，可改善患者凝血功能，減輕炎癥反應(yīng)，降低ox-LDL和HFABP水平，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical efficacy of Salvianolic Acids for Injection combined with atorvastatin in treatment of acute cerebral infarction and its effect on ox-LDL and H-FABP. Methods A total of 86 patients with acute cerebral infarction admitted to General Hospital of Hebi Coal Industry (Group) Co., Ltd from June 2017 to December 2018 were selected as study subjects. Patients were randomly divided into control group (n=43) and observation group (n=43) by random number table method. Patients in the control group po administered with Atorvastatin Calcium Tablets, 20 mg/time, once daily. Patients in the observation group were iv adminintered with Salvianolic Acids for Injection on the basis of control group, 100 mg was added to 250 mL normal saline, once daily. The course of treatment in both groups was 14 d. The clinical efficacy in two groups of patients was observed, and the coagulation function, inflammatory mediators, ox-LDL and H-FABP levels in two groups before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 93.02%, significantly higher than 72.09% in the control group (P<0.05). After treatment, the levels of Fib and D-dimer indexes in two groups were significantly decreased (P<0.05). After treatment, the levels of Fib and D-dimer indexes in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of IL-18, TNF-α, and MMP-9 in two groups were significantly decreased (P<0.05). After treatment, the levels of IL-18, TNF-α, and MMP-9 in the observation group were significantly lower than those in the control group (P<0.05). After treatment, ox-LDL and H-FABP levels in both groups were significantly decreased (P<0.05). After treatment, ox-LDL and H-FABP levels in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Salvianolic Acids for Injection combined with atorvastatin in treatment of patients with acute cerebral infarction has obvious curative effect, which can improve patients' blood coagulation function, reduce the inflammatory response, and ox-LDL and H-FABP levels, which has a certain clinical application value.

R971