結(jié)直腸癌是世界上第3大常見(jiàn)癌癥，化療貫穿整個(gè)治療過(guò)程，但其耐藥的發(fā)生成為癌癥死亡和復(fù)發(fā)的主要原因，亟需尋找輔助化療藥治療的藥物增加其療效。姜黃素是美國(guó)國(guó)立腫瘤學(xué)會(huì)所承認(rèn)的廣譜抗癌藥物，其作用機(jī)制是通過(guò)調(diào)控相關(guān)蛋白表達(dá)、上皮間充質(zhì)轉(zhuǎn)化分子標(biāo)志物、結(jié)直腸癌干細(xì)胞識(shí)別標(biāo)志物、相關(guān)信號(hào)通路、自噬和相關(guān)因子。綜述姜黃素逆轉(zhuǎn)逆轉(zhuǎn)結(jié)直腸癌化療耐藥的機(jī)制，旨在為科研探索和臨床治療、預(yù)防提供更好的研究思路和應(yīng)用價(jià)值。

Colorectal cancer is the third most common cancer in the world. Chemotherapy runs through the whole process of cancer treatment, but its drug resistance has become the main cause of cancer death and recurrence. Therefore, there is an urgent need to find adjuvant chemotherapeutic drugs to increase its efficacy. Curcumin is a broad-spectrum anticancer drug recognized by the American National Society of Oncology. its mechanism is through the regulation of related protein expression, epithelial mesenchymal transformation molecular markers, colorectal cancer stem cell recognition markers, related signal pathways, autophagy and related factors. Therefore, the mechanism of reversing chemotherapy resistance is reviewed in order to provide better research ideas and application value for scientific research, clinical treatment and prevention.

R285.5;R979.1

國(guó)家自然基金面上項(xiàng)目（81973728）；天津市自然科學(xué)基金資助項(xiàng)目（18JCZDJC36600）