結(jié)直腸癌是世界上第3大常見癌癥，化療貫穿整個治療過程，但其耐藥的發(fā)生成為癌癥死亡和復發(fā)的主要原因，亟需尋找輔助化療藥治療的藥物增加其療效。姜黃素是美國國立腫瘤學會所承認的廣譜抗癌藥物，其作用機制是通過調(diào)控相關(guān)蛋白表達、上皮間充質(zhì)轉(zhuǎn)化分子標志物、結(jié)直腸癌干細胞識別標志物、相關(guān)信號通路、自噬和相關(guān)因子。綜述姜黃素逆轉(zhuǎn)逆轉(zhuǎn)結(jié)直腸癌化療耐藥的機制，旨在為科研探索和臨床治療、預防提供更好的研究思路和應用價值。

Colorectal cancer is the third most common cancer in the world. Chemotherapy runs through the whole process of cancer treatment, but its drug resistance has become the main cause of cancer death and recurrence. Therefore, there is an urgent need to find adjuvant chemotherapeutic drugs to increase its efficacy. Curcumin is a broad-spectrum anticancer drug recognized by the American National Society of Oncology. its mechanism is through the regulation of related protein expression, epithelial mesenchymal transformation molecular markers, colorectal cancer stem cell recognition markers, related signal pathways, autophagy and related factors. Therefore, the mechanism of reversing chemotherapy resistance is reviewed in order to provide better research ideas and application value for scientific research, clinical treatment and prevention.

R285.5;R979.1

國家自然基金面上項目（81973728）；天津市自然科學基金資助項目（18JCZDJC36600）