目的 探討宮頸癌患者中HNF1A-AS1、HNF1A的表達及其臨床意義。方法 選取2013年-2018年延安市人民醫(yī)院收集的187例宮頸癌患者的癌組織及對應的癌旁正常組織標本，通過實時熒光定量PCR檢測宮頸癌患者腫瘤組織中HNF1A-AS1、HNF1A的表達情況，探討HNF1A-AS1、HNF1A表達水平與宮頸癌患者臨床特征和生存期之間的關系。結果 HNF1A-AS1在宮頸癌組織中高表達（P=0.022）；HNF1A-AS1高表達與宮頸癌患者腫瘤分期（P<0.001）、是否原位癌（P=0.013）、是否淋巴結轉移（P=0.002）、是否遠端轉移（P<0.001）以及HPV型別相關（P=0.006）；HNF1A-AS1高表達組總體生存率明顯低于HNF1A-AS1低表達組（χ²=10.33，P=0.002）。HNF1A在宮頸癌組織中高表達（P=0.044），且HNF1A的相對表達量與HNF1A-AS1表達呈正相關（P<0.001）；HNF1A高表達與宮頸癌患者腫瘤分期（P=0.002）、是否原位癌（P=0.007）、是否淋巴結轉移（P=0.005）、是否遠端轉移（P<0.001）以及HPV型別相關（P=0.003）；HNF1A高表達組總體生存率明顯低于HNF1A低表達組（χ²=6.10，P=0.013）。結論 HNF1A-AS1、HNF1A促進宮頸癌發(fā)生和發(fā)展，并與宮頸癌患者生存期相關。

Objective To investigate the expression and clinical significance of HNF1A-AS1 and HNF1A in patients with cervical cancer.Methods The cancer tissues and corresponding normal adjacent tissues of 187 cervical cancer patients collected in Yan'an People's Hospital from 2013 to 2018 were selected, and the expression levels of HNF1A-AS1 and HNF1A in the tumor tissues of cervical cancer patients were detected by real-time fluorescence quantitative PCR, so as to explore the relationship between the expression of HNF1A-AS1 and HNF1A, and the clinical characteristics, survival time of cervical cancer patients. Results HNF1AAS1 was highly expressed in cervical cancer tissues (P=0.022). High HNF1A-AS1 expression was associated with tumor stage (P<0.001), carcinoma in situ (P=0.013), lymph node metastasis (P=0.002), distal metastasis (P<0.001), and HPV type (P=0.006) in patients with cervical cancer. The overall survival rate of the HNF1A-AS1 high expression group was significantly lower than that of the HNF1A-AS1 low expression group (χ²=10.33, P=0.002). HNF1A was highly expressed in cervical cancer tissues (P=0.044), and the relative expression of HNF1A was positively correlated with the expression of HNF1A-AS1 (P<0.001). High expression of HNF1A was associated with tumor stage (P<0.002), carcinoma in situ (P=0.007), lymph node metastasis (P=0.005), distal metastasis (P<0.001), and HPV type (P=0.003) in patients with cervical cancer. The overall survival rate of the HNF1A-AS1 high expression group was significantly lower than that of the low expression group (χ²=6.10, P=0.013). Conclusion HNF1A-AS1 and HNF1A promote the occurrence and development of cervical cancer, and are related to the survival of cervical cancer patients.

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