異檸檬酸脫氫酶（IDH）1和2是細胞代謝的關鍵酶，參與多個生理過程。IDH突變（mIDH）在腫瘤發(fā)展中起關鍵或決定性作用，是膠質瘤藥物開發(fā)的重要靶點。制藥企業(yè)不斷開發(fā)針對mIDH的抑制劑，Ivosidenib和Enasidenib已被FDA批準用于治療復發(fā)難治性急性髓細胞性白血?。ˋML），并進一步開展針對膠質瘤的試驗；Olutasidenib，Vorasidenib，NOA-16等正在進行Ⅰ/Ⅱ期臨床試驗；AGI-5198，GSK-321等止步于臨床前研究。對這些小分子抑制劑和疫苗的臨床前研究成果及臨床試驗進展進行總結，以期為膠質瘤藥物開發(fā)提供參考。

Isocitrate dehydrogenase (IDH) 1 and 2 are key enzymes in cell metabolism,which participate in multiple physiological processes. Mutant IDHs (mIDH) play a key or decisive role in tumor development and have become a kind of important targets for glioma drug. Pharmaceutical companies continue to develop inhibitors against mIDH. Ivosidenib and Enasidenib have been approved by the FDA for the treatment of relapsed or refractory acute myeloid leukemia (AML), which are continued to be studied in trials in glioma; Olutasidenib, Vorasidenib, NOA-16 and some other inhibitors are under phase Ⅰ/Ⅱ clinical trials; AGI-5198, GSK-321, etc. have stopped in preclinical research. In this review, we summarize the preclinical research results and clinical trial progress of some small molecule inhibitors and vaccines, hoping to provide a reference for the development of glioma drugs.

R979.1

天津市科技計劃項目（17ZXXYSY00050）