目的 探討多索茶堿聯(lián)合氨溴索對(duì)小兒哮喘患者的臨床療效及其對(duì)T淋巴細(xì)胞亞群和肺功能的影響。方法 選取格爾木市人民醫(yī)院2017年1月—2019年1月收治的60例小兒哮喘患者作為研究對(duì)象，按照隨機(jī)雙盲法將患兒分為對(duì)照組和觀察組，每組各30例。對(duì)照組患兒靜脈滴注鹽酸氨溴索注射液，將藥物加入到葡萄糖注射液（或生理鹽水）中，2~6歲兒童：7.5 mg/次，3次/d；2歲以下兒童：7.5 mg/次，2次/d。觀察組患者在對(duì)照組治療的基礎(chǔ)上靜脈滴注多索茶堿注射液，100 mg/次，以25%葡萄糖注射液稀釋至40 mL，時(shí)間應(yīng)在20 min以上。兩組患者均以2周為1個(gè)療程，兩組患者均治療1個(gè)療程。觀察兩組患者的臨床療效，同時(shí)比較兩組治療前后的T淋巴細(xì)胞亞群和肺功能的水平。結(jié)果 治療后，觀察組患者的治療總有效率為93.3%，明顯高于對(duì)照組的73.3%（P<0.05）。治療后，兩組患者各項(xiàng)T淋巴細(xì)胞亞群水平明顯優(yōu)于治療前（P<0.05），且觀察組各項(xiàng)T淋巴細(xì)胞亞群水平明顯優(yōu)于對(duì)照組（P<0.05）。治療后，兩組患者各項(xiàng)肺功能指標(biāo)均較治療前改善（P<0.05），而觀察組患者各項(xiàng)肺功能指標(biāo)治療后比治療前變化幅度明顯大于對(duì)照組（P<0.05）。結(jié)論 多索茶堿聯(lián)合氨溴索治療小兒哮喘可獲取顯著的治療效果，可有效改善患者T淋巴細(xì)胞亞群水平，改善肺功能，具有重要的臨床價(jià)值。

Objective To investigate the clinical effect of doxofylline combined with ambroxol on children with asthma and its effect on T lymphocyte subsets and lung function. Methods A total of 60 pediatric asthma patients admitted to Golmud People's Hospital from January 2017 to January 2019 were selected as the research objects. According to the randomized double-blind method, the children were divided into the control group and the observation group, with 30 patients in each group. Children in the control group were iv administered with Ambroxol Hydrochloride Injection, and the drug was added to glucose injection (or normal saline). Children aged two to six years were 7.5 mg/time, three times daily. Children under two years were 7.5 mg/time, twice daily. Children in the observation group were iv administered with Doxofylline Injection on the basis of control group, 100 mg/time, and diluted with 25% glucose injection to 40 mL for the time of more than 20 min. Patients in two groups were received one course of treatment for 2 weeks. The clinical efficacy in two groups was observed, and the T lymphocyte subsets and lung function levels in two groups before and after treatment were compared. Results After treatment, the total effective rate in the observation group was 93.3%, which was significantly higher than 73.3% in the control group (P<0.05). After treatment, the levels of T lymphocyte subsets in two groups were significantly better than those before treatment (P<0.05), and the levels of T lymphocyte subsets in the observation group were significantly better than those in the control group (P<0.05). After treatment, lung function indicators in two groups were improved compared with that before treatment (P<0.05), while the changes of lung function indicators in the observation group were significantly larger than those in the control group (P<0.05). Conclusion Doxofylline combined with ambroxol in treatment of childhood asthma can obtain significant therapeutic effect, can effectively improve the level of T lymphocyte subsets, improve lung function, has important clinical value.

R974;R985