目的 系統(tǒng)的評價外用他克莫司（軟膏或漱口水）治療糜爛型口腔扁平苔蘚的有效性和安全性。方法 計算機檢索PubMed、EMbase、Cochrane Library、OVID、中國學術期刊全文數(shù)據(jù)庫（CNKI）、中國生物醫(yī)學文獻數(shù)據(jù)庫（CBM）、維普中文期刊全文數(shù)據(jù)庫（VIP）和萬方數(shù)據(jù)庫，檢索年限均為數(shù)據(jù)庫建庫至2019年12月，搜索他克莫司（軟膏或漱口水）與皮質類固醇藥物（對照藥）比較治療糜爛型口腔扁平苔蘚的臨床隨機對照試驗（RCTs），采用Stata1 4.2軟件進行Meta-分析。結果 共納入23個RCTs、共1 269例患者。Meta-分析結果顯示：與對照組比較治療組有效率（RR=1.11，95% CI=1.02~1.22，P=0.022）及安全性（RR=0.62，95% CI=0.44~0.88，P=0.007）均有統(tǒng)計學差異（P<0.05），其中0.03%他克莫司比0.1%他克莫司更安全。結論 治療糜爛型口腔扁平苔蘚，他克莫司較皮質類固醇藥物的安全性更好，不良反應更低。

Objective To systematically evaluate the efficacy and safety of topical tacrolimus (ointment or mouthwash) in the treatment of erosive oral lichen planus. Methods The databases PubMed, EMbase, the Cochrane Library, OVID, CNKI, CBM, VIP and Wanfang Data were searched for controlled trials (RCTs) of tacrolimus (ointment or mouthwash) compared with corticosteroid drug (placebo) in the treatment of erosive oral lichen planus, from database building to December 2019. Meta-analysis was performed using Stata1 4.2 software. Results A total of 23 RCTs with 1 269 patients were included. Meta-analysis results showed that compared with the control group, the effective rate (RR=1.11, 95% CI=1.02-1.22, P=0.022) and safety (RR=0.62, 95% CI=0.44-0.88, P=0.007) of the treatment group were statistically significant differences (P<0.05), and the 0.03% concentration was safer than the 0.1% concentration. Conclusion Tacrolimus is safer and has fewer adverse reactions than corticosteroid in the treatment of erosive oral lichen planus.

R988.2

國家癌癥中心攀登基金項目（NCC201803B006）；河北省科技廳重點研發(fā)項目（18277730D）；河北省衛(wèi)生廳科研基金項目（20170691）