女貞子藥對及女貞子的活性成分紅景天苷、齊墩果酸和熊果酸均有平喘作用。紅景天苷、齊墩果酸和熊果酸有抗脂多糖、膿毒癥、休克、百草枯、氯氣、油酸和缺氧引起的急性肺損傷作用，也有抗缺氧、香煙煙霧、二氧化硅、博來霉素和野百合堿引起的慢性肺損傷和肺纖維化作用。它們的肺保護(hù)作用的共同機(jī)制可能是：（1）上調(diào)T-bet基因表達(dá)和下調(diào)GATA3基因表達(dá)，調(diào)節(jié)Th1/Th2之間的平衡，抑制IgE生成和炎性細(xì)胞因子表達(dá)，減輕肺和氣道的炎癥反應(yīng)；（2）上調(diào)Nrf-2通路，發(fā)揮抗氧化作用，減輕肺組織的氧化應(yīng)激反應(yīng)引起的炎性肺損傷；（3）激活PI3K/AKT信號通路和阻滯TLR4/MyD88/NF-κB炎性信號通路，保護(hù)肺上皮細(xì)胞；（4）阻滯TGF-β1/Smad通路，抑制膠原合成和成纖維細(xì)胞增生，減輕肺纖維化形成。女貞子藥對和紅景天苷有抗病毒性肺炎作用，齊墩果酸和熊果酸具有廣譜抗病毒作用，除了直接抗病毒作用外，提高機(jī)體的免疫功能也是作用機(jī)制之一。

Fructus Ligustri Lucidi pair and the active components of Fructus Ligustri Lucidi(salidroside, oleanolic and usrolic acids) have antiasthmatic effects. Salidroside, oleanolic and usrolic acids have the antagonisms on acute lung injuries induced by lipopolysaccharide, sepsis, shock, paraquat, chlorine, oleic acid and hypoxia, and the antagonisms on chronic lung injuries and pulmonary fibrosis induced by hypoxia, cigarette smoke, SiO2, bleomycin, monocrotaline. The common mechanisms of lung protection may be:(1) up-regulating the expression of Tebt mRNA, and down-regulating the expression of GATA3 mRNA, to regulate the Th1/Th2 balance, to inhibt the the expression of IgE and inflammatory cytokines, so can alleviate inflammation of lung and airway; (2) up-regulating Nrf-2 pathway to show antioxidation, so can alleviate oxidation stress-induced lung inflammatory injury; (3) activating PI3K/AKT pathway and blocking TLR4/MyD88/NF-κB pathway to protect pulmonary epithelial cells; (4) blocking TGFβ1/Smad pathway to inhibit collagen synthesis and fibrocyte hyperplasia, so can alleviate pulmonary fibrogenesis. Fructus Ligustri Lucidi pair and salidroside have the effects against virus pneumonia. Oleanolic and usrolic acids have broad-spectrum antiviral effects. The mechanisms are direct effect against virus, and promote organism immunopotency against virus.

R285.5;R964