目的 研究陰道用乳桿菌活菌膠囊聯(lián)合婦陰康洗劑治療混合性陰道炎患者的療效及對陰道菌群的影響。方法 選取2018年6月-2019年6月北京市豐臺區(qū)婦幼保健院診治的混合性陰道炎患者112例作為研究對象，將所有患者隨機分為對照組（n=56）與觀察組（n=56）。對照組患者給予陰道用乳桿菌活菌膠囊，每晚患者用溫清水將外陰部清洗后擦干，將雙手洗凈，仰臥，食指戴內(nèi)含一次性無菌手指套，取出1粒放置于陰道深處，1粒/次，1次/d。觀察組在對照組治療的基礎(chǔ)上給予婦陰康洗劑治療，用溫清水將外陰部清洗后擦干，患者仰臥，取10 mL洗劑注入陰道內(nèi)，將液體在陰道內(nèi)維持20 min，防止藥液外流，每晚1次。10 d為1個療程。兩組均治療2個療程。觀察兩組患者的臨床療效、復(fù)發(fā)率，對比兩組的陰道pH值、清潔度、陰道菌群分布和癥狀改善時間。結(jié)果 治療后，對照組和觀察組的總有效率分別為83.93%、96.43%，復(fù)發(fā)率分別為26.79%和3.57%，兩組臨床療效和復(fù)發(fā)率比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者陰道pH值低于治療前（P<0.05）；治療后，觀察組陰道pH值、清潔度III度顯著低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者檢出乳桿菌高于治療前，酵母菌、腸桿菌、葡萄球菌檢出個數(shù)低于治療前（P<0.05）；治療后，觀察組乳桿菌高于對照組，且酵母菌、腸桿菌、葡萄球菌檢出個數(shù)低于對照組（P<0.05）。治療后，觀察組白帶增多、異味、外陰瘙癢、陰道灼痛癥狀改善時間顯著短于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 陰道用乳桿菌活菌膠囊聯(lián)合婦陰康洗劑治療混合性陰道炎患者具有顯著療效，并可恢復(fù)陰道菌群平衡。

Objective To study the efficacy of Live Lactobacillus Capsule for vaginal combined with Fuyinkang Lotion in treatment of mixed vaginitis and its influence on vaginal microflora. Methods A total of 112 patients with mixed vaginitis treated in Fengtai District Maternal & Child Health Hospital from June 2018 to June 2019 were selected as the research objects, and all the patients were randomly divided into the control group (n=56) and the observation group (n=56). Patients in the control group were given Live Lactobacillus Capsule for vaginal, patients washed genitals with warm water and dried every night, wore disposable sterile finger sleeve with index finger, took out one capsule and placed it deep in the vagina, one capsule per time, and once daily. Patients in the observation group were treated with Fuyinkang Lotion on the basis of control group, took 10 mL lotion and inject it into the vagina. Keep the liquid in the vagina for 20 min to prevent the outflow of the liquid, once a night. 10 days as one course of treatment. Both groups received 2 courses of treatment. The clinical efficacy and recurrence rate of two groups were observed, and the vaginal pH value, cleanliness, distribution of vaginal microflora, and symptom improvement time of two groups were compared. Results After treatment, the total effective rates of the control group and the observation group were 83.93% and 96.43%, respectively, and the recurrence rates were 26.79% and 3.57%, respectively. There were statistically significant differences in the clinical efficacy and recurrence rates between two groups (P<0.05). After treatment, the pH value of vagina was lower than that before treatment (P<0.05). After treatment, pH value and cleanliness III of the vagina in the observation group were significantly lower than those in the control group, with statistically significant differences (P<0.05). After treatment, the number of lactobacillus detected in two groups was higher than that before treatment, and the number of yeast, enterobacteria, and staphylococcus detected in two groups was lower than that before treatment (P<0.05). After treatment, the number of lactobacillus in the observation group was higher than that in the control group, and the number of yeast, enterobacter, and staphylococcus in the observation group was lower than that in the control group (P<0.05). After treatment, the improvement time of increased leucorrhea, peculiar smell, vulva pruritus, and vaginal burning symptoms in the observation group was significantly lower than that in the control group, with statistically significant differences (P<0.05). Conclusion Live Lactobacillus Capsule for vaginal combined with Fuyinkang Lotion in treatment of mixed vaginitis has a significant effect, and can restore the balance of vaginal flora.

R984