目的 探討婦科千金膠囊聯(lián)合左氧氟沙星治療慢性宮頸炎的臨床療效。方法 選取2016年5月-2019年5月在延安市人民醫(yī)院婦產(chǎn)科治療慢性宮頸炎的患者286例作為研究對(duì)象，根據(jù)入院?jiǎn)坞p號(hào)分為對(duì)照組和觀察組，每組各143例。對(duì)照組患者口服鹽酸左氧氟沙星片，0.5 g/次，1次/d；觀察組患者在對(duì)照組的基礎(chǔ)上口服婦科千金膠囊，0.8 g/次，3次/d。兩組均連續(xù)治療4周。觀察兩組患者的臨床療效和不良反應(yīng)情況，同時(shí)比較兩組治療前后的癥狀評(píng)分、血清學(xué)指標(biāo)。結(jié)果 治療后，觀察組治療總有效率為95.80%，顯著高于對(duì)照組的79.03%（P<0.05）。治療后，兩組的癥狀評(píng)分均顯著降低（P<0.05），且觀察組顯著低于對(duì)照組（P<0.05）。治療后，兩組白細(xì)胞介素-6（IL-6）、超敏C-反應(yīng)蛋白（hs-CRP）和腫瘤壞死因子-α（TNF-α）水平均明顯降低（P<0.05），血管內(nèi)皮生長(zhǎng)因子（VEGF）和自然殺傷T細(xì)胞（NKTs）水平明顯升高，且觀察組上述血清學(xué)指標(biāo)均顯著優(yōu)于對(duì)照組（P<0.05）。治療期間，對(duì)照組不良反應(yīng)發(fā)生率為15.38%，顯著高于觀察組的4.20%（P<0.05）。結(jié)論 婦科千金膠囊聯(lián)合左氧氟沙星可有效抑制機(jī)體炎性反應(yīng)，加速癥狀緩解及宮頸修復(fù)，療效安全顯著，對(duì)促進(jìn)慢性宮頸炎病情康復(fù)具有積極意義，值得臨床推廣應(yīng)用。

Objective To investigate the clinical effect of Fuke Qianjin Capsules combined with levofloxacin in treatment of chronic cervicitis. Methods A total of 286 patients with chronic cervicitis treated in the department of Obstetrics and Gynecology of Yan'an People's Hospital from May 2016 to May 2019 were selected as the research objects, and were divided into control group and observation group according to the odd and even number of admission, with 143 patients in each group. Patients in the control group were po administered with Levofloxacin Hydrochloride Tablets, 0.5 g/time, and once daily. Patients in the observation group were po administered with Fuke Qianjin Capsules on the basis of the control group, 0.8 g/time, and three times daily. Both groups were treated continuously for 4 weeks. The clinical efficacy and adverse reactions in two groups were observed, and the symptom scores and serological indicators before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 95.80%, which was significantly higher than 79.03% of the control group (P<0.05). After treatment, the symptom scores in two groups were significantly reduced (P<0.05), and the observation group was significantly lower than control group (P<0.05). After treatment, the levels of IL-6, hs-CRP, and TNF-α were significantly decreased in two groups (P<0.05), but the levels of VEGF and NKTs were significantly increased. Moreover, the serological indicators in the observation group were significantly better than those in the control group (P<0.05). During the treatment, the incidence of adverse reactions in the control group was 15.38%, significantly higher than 4.20% in the observation group (P<0.05). Conclusion Fuke Qianjin Capsules combined with levofloxacin can effectively inhibit the body's inflammatory response, accelerate the relief of symptoms and cervical repair, with a safe and significant effect, and has positive significance in promoting the rehabilitation of chronic cervicitis, which is worthy of clinical promotion and application.

R984