目的 分析枸櫞酸氯米芬聯(lián)合注射用尿促性素治療多囊卵巢綜合征不孕癥患者的療效。方法 選取2017年9月-2019年9月在渭南市中心醫(yī)院進(jìn)行治療的多囊卵巢綜合征不孕癥患者96例作為研究對(duì)象，根據(jù)治療方式不同將患者分為對(duì)照組和觀察組，每組各48例。對(duì)照組患者肌肉注射注射用尿促性素進(jìn)行治療，患者均于月經(jīng)周期第5天開(kāi)始用藥，1支/次，1次/d。觀察組患者在對(duì)照組的基礎(chǔ)上于月經(jīng)周期第5天開(kāi)始口服枸櫞酸氯米芬膠囊，100 mg/次，1次/d。兩組均連續(xù)用藥5 d。觀察兩組患者的子宮內(nèi)膜厚度、直徑超過(guò)18 mm的卵泡數(shù)和卵泡成熟時(shí)間，并比較兩組的性激素水平、排卵率、妊娠率和流產(chǎn)率。結(jié)果 治療后，觀察組直徑超過(guò)18 mm的卵泡數(shù)、子宮內(nèi)膜厚度均明顯多于（優(yōu)于）對(duì)照組；卵泡成熟時(shí)間顯著短于對(duì)照組（P<0.05）。治療后，兩組雌二醇（E₂）、孕激素（P）、卵泡雌激素（FSH）水平均升高，黃體生成素（LH）水平均降低（P<0.05），且觀察組患者更顯著（P<0.05）。治療后，觀察組排卵率、妊娠率均明顯高于對(duì)照組，流產(chǎn)率明顯低于對(duì)照組（P<0.05）。結(jié)論 枸櫞酸氯米芬聯(lián)合注射用尿促性素治療多囊卵巢綜合征可改善患者卵泡、子宮內(nèi)膜發(fā)育情況和性激素水平，有利于增加患者妊娠率，值得臨床上廣泛使用。

Objective To analyze the efficacy of clomifene citrate combined with Homoharringtonine for Injection in treatment of infertility patients with polycystic ovary syndrome. Methods A total of 96 infertility patients with polycystic ovary syndrome who were treated in Weinan Central Hospital from September 2017 to September 2019 were selected as research objects. According to different treatment methods, the patients were divided into control group and observation group, with 48 patients in each group. Patients in the control group were treated by intramuscular injection of Homoharringtonine for Injection, which were started on the fifth day of the menstrual cycle, once daily. Patients in the observation group were po administered with Clomifene Citrate Tablets on the basis of the control group, 100 mg/time, and once daily. Both groups were treated consecutively for 5 days. After treatment, the endometrial thickness, follicular number with diameter over 18 mm, and follicular maturation time of two groups were observed, and the sex hormone levels, ovulation rate, pregnancy rate, and abortion rate in two groups were compared. Results After treatment, endometrial thickness and follicular number with diameter over 18 mm in the observation group were significantly higher than (superior to) the control group, follicular maturation time was significantly shorter than that of the control group(P<0.05). After treatment, E₂, P, and FSH levels were increased in two groups, while LH levels were decreased (P<0.05), which was more significant in the observation group (P<0.05). After treatment, the ovulation rate and pregnancy rate of the observation group were significantly higher than those of the control group, and the abortion rate was significantly lower than that of the control group (P<0.05). Conclusion Clomifene citrate combined with Homoharringtonine for Injection in treatment of infertility patients with polycystic ovary syndrome can improve the development of follicles, endometrium, and sex hormone levels in patients, and is beneficial to increase the pregnancy rate of patients, which is worthy of wide clinical use.

R977.1