目的 運(yùn)用數(shù)據(jù)挖掘技術(shù)研究黃力教授治療老年高血壓的用藥規(guī)律。方法 收集2013年1月1日-2018年12月31日中日友好醫(yī)院黃力教授專(zhuān)家門(mén)診處方數(shù)據(jù)，進(jìn)行整理和篩選，應(yīng)用頻數(shù)分析、關(guān)聯(lián)規(guī)則分析及聚類(lèi)分析方法進(jìn)行專(zhuān)家處方的挖掘與探索。結(jié)果 共收集處方275首，涉及中藥197味，累計(jì)用藥頻次4 317次。其中高頻藥物的藥性以平、溫、微寒為主，藥味以甘、辛、苦為主，歸經(jīng)以肝、脾、心經(jīng)為主，所屬中藥功效以平肝熄風(fēng)、補(bǔ)虛、活血化瘀、安神類(lèi)為主，所屬分類(lèi)以平抑肝陽(yáng)、補(bǔ)氣、養(yǎng)心安神、活血調(diào)經(jīng)類(lèi)為主。關(guān)聯(lián)規(guī)則分析總結(jié)出用藥核心配伍組合為"葛根-川芎-龍骨-牡蠣-天麻"。聚類(lèi)分析顯示高頻藥物可分為4類(lèi)：重鎮(zhèn)安神、活血通絡(luò)類(lèi)；平肝補(bǔ)腎類(lèi)；健脾燥濕化痰類(lèi)；養(yǎng)心安神、益氣活血類(lèi)。結(jié)論 黃力教授治療老年高血壓用藥多取甘辛平溫之品，注重平肝潛陽(yáng)、鎮(zhèn)驚安神，同時(shí)兼顧活血理氣、滋補(bǔ)肝腎、養(yǎng)心安神?？偨Y(jié)其處方思路為：以核心藥對(duì)川芎-葛根、龍骨-牡蠣為基礎(chǔ)，配天麻鉤藤飲合半夏白術(shù)天麻湯加減，佐以益氣活血、養(yǎng)心安神類(lèi)藥物。

Objective To study the medication rule of Professor Huang Li in treatment of elderly hypertension by using data mining technology. Methods The data of outpatient prescriptions of Huang Li expert in China Japan Friendship Hospital from January 1, 2013 to December 31, 2018,were collected,sorted and screened. Frequency analysis, association rule analysis and cluster analysis were used to mine and explore expert prescriptions. Results A total of 275 prescriptions were collected,involving 197 flavors of traditional Chinese medicine (TCM), with a cumulative frequency of 4 317 times. Among them, the high-frequency drugs are mainly composed of mild, warm and slightly cold properties; the main tastes are sweet, pungent and bitter; the meridians are mainly liver, spleen and heart meridian; the TCM categories are mainly for calming the liver wind, tonifying the deficiency, promoting blood circulation and removing blood stasis, and calming nerves; the classification is mainly for suppressing liver Yang, tonifying Qi, nourishing heart and tranquilizing mind, and promoting blood circulation and regulating menstruation. According to association rule analysis, the core compatibility combination was "Gegen-Chuanxiong-Longgu-Muli-Tianma". Cluster analysis showed that highfrequency drugs could be divided into four categories:calming the nerves, promoting blood circulation and dredging collaterals; smoothing the liver and tonifying the kidney; invigorating the spleen, drying dampness and resolving phlegm;nourishing the heart and tranquilizing the mind, invigorating qi and activating blood circulation. Conclusion Professor Huang Li often uses sweet, pungent, midl and warm drugs in the treatment of elderly hypertension, focusing on calming the liver and suppressing yang, calming the nerves, and promoting blood circulation and regulating Qi, nourishing the liver and kidney, nourishing the heart and tranquilizing the mind. To sum up her prescription ideas:Based on the core drug pair of Gegen-Chuanxiong and Longgu-Muli, combined with Tianma Gouteng Decoction and Banxia Baizhu Tianma Decoction, supplemented with drugs of nourishing the heart and tranquilizing the mind, invigorating Qi and activating blood circulation.

R914.2;R286.2

國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目（81774105）