苦參堿具有廣泛的生物活性，如保護(hù)心、肝、肺、腎、腦、血管作用，對心臟有正性肌力、負(fù)性頻率、抗心律失常作用，還有升高白細(xì)胞，平喘，抗?jié)儯垢卫w維化以及鎮(zhèn)靜、催眠、鎮(zhèn)痛等中樞神經(jīng)藥理作用，也具有抗腫瘤、免疫調(diào)節(jié)、抗菌、抗病毒、抗炎等藥理作用。其中抗腫瘤、心血管保護(hù)和治療病毒性肺炎的藥理作用的研究比較深入，希望生產(chǎn)企業(yè)開發(fā)苦參堿的這些新適應(yīng)癥?？鄥A是一種親水性的弱堿性藥物，易透過生物膜，口服和經(jīng)皮給藥易吸收和分布，約50%原型苦參堿經(jīng)尿排泄。通過綜述苦參堿藥動學(xué)參數(shù)、體內(nèi)過程，總結(jié)苦參堿的藥動學(xué)研究進(jìn)展，為合理用藥提供參考。推薦將苦參堿試用于病毒性肺炎的治療。

Matrine has a widespread bioactivities, including protection of heart, liver, lung, kidney, brain and blood vessel, and the effects of positive inotropism, negative chronotropism and antiarrhythmia on heart, and promoting leukocytes, antiasthma, antiulcer, anti-fibrogenesis in liver, and central suppression of sedation, hypnogenesis, analgesia, and antitumor, immunoregulation, antibacteria, anti-virus and anti-inflammation. Amomg them the pharmacologic effects of antitumor, cardiovascular protections, and treatment for viral pulmonitis have be deeply researched, those new indications of matrine are remaining to enterprises to develop. Matrine is a hydrophilic and weakly alkaline drug to easily penetrated through biomembrane. Matrine oral and transdermal administration is easily absorbed and distributed. About 50% prototype matrine is excreted from urine. The pharmacokinetic parameters and process in body of matrine are reviewed, and its research advances on pharmacokinetics is summarized, which provides a reference for rational utilization of matrine. So recommend matrine to try on treatment for viral pulmonitis. We recommend matrine to try on treatment for viral pulmonitis.

R285.5;R945