脂質(zhì)是機(jī)體內(nèi)重要的營(yíng)養(yǎng)物質(zhì)之一，參與機(jī)體的能量供應(yīng)、生物膜形成以及代謝調(diào)節(jié)等，內(nèi)質(zhì)網(wǎng)是其合成的主要場(chǎng)所。近年來(lái)越來(lái)越多研究表明，細(xì)胞色素P450酶的表達(dá)和活性影響機(jī)體對(duì)有害物質(zhì)的敏感性以及藥物的療效，影響疾病的發(fā)生及發(fā)展，而細(xì)胞色素P450酶作為膜蛋白受到膜組成的影響。就細(xì)胞色素P450酶調(diào)控過(guò)程中內(nèi)質(zhì)網(wǎng)脂質(zhì)穩(wěn)態(tài)的作用進(jìn)行綜述。

Lipid is one of the important nutrients in the body. It is involved in energy supply, formation of biomembrane and metabolic regulation. Endoplasmic reticulum is the main site for enzyme synthesis. In recent years, more and more reports have shown that the expression and activity of P450s affect the body's sensitivity to harmful substances and the efficacy of drugs, which affects the occurrence and development of diseases. Metabolic enzymes are membrane proteins so that they can be affected by the composition of membrane. In this review, we summarized the function of endoplasmic lipid homeostasis in P450s regulation.

國(guó)家自然科學(xué)基金面上項(xiàng)目（81872932）