目的 探討前列地爾聯(lián)合百令膠囊治療慢性腎臟病患者的臨床療效。方法 選取2016年4月—2019年4月喀什地區(qū)第一人民醫(yī)院98例早期慢性腎臟病患者作為研究對(duì)象，根據(jù)隨機(jī)數(shù)字表法將受試者分為對(duì)照組和觀察組，每組各49例。對(duì)照組患者溫水送服百令膠囊，2.5 g/次，3次/d。觀察組在對(duì)照組的基礎(chǔ)上將2 mL前列地爾注射液加入到0.9%的氯化鈉20 mL中靜脈推注，1次/d。兩組均連續(xù)治療1個(gè)月。觀察兩組患者的臨床療效，同時(shí)比較兩組治療前后的腎功能指標(biāo)和炎性因子水平。結(jié)果 治療后，對(duì)照組和觀察組的總有效率分別為75.51%、91.84%，兩組總有效率比較存在統(tǒng)計(jì)學(xué)差異（P<0.05）。治療后，兩組各腎功能指標(biāo)肌酐（Scr）、尿素氮（BUN）、24 h尿蛋白定量（Upro）均顯著降低，腎小球?yàn)V過(guò)率評(píng)估值（eGFR）顯著升高（P<0.05），且觀察組各指標(biāo)顯著優(yōu)于對(duì)照組（P<0.05）。治療后，兩組血清腫瘤壞死因子（TNF）-α、超敏C反應(yīng)蛋白（hs-CRP）、白細(xì)胞介素（IL）-18水平均明顯降低，且觀察組低于對(duì)照組（P<0.05）。結(jié)論 前列地爾聯(lián)合百令膠囊可有效改善慢性腎臟病患者的腎功能，調(diào)節(jié)免疫，療效安全顯著，對(duì)促進(jìn)早期慢性腎臟病患者病情康復(fù)具有積極意義。

Objective To investigate the effect of alprostadil combined with Bailing Capsule in treatment of chronic kidney disease. Methods A total of 98 patients with early chronic kidney disease in the First People's Hospital of Kashgar from April 2016 to April 2019 were selected as the research objects, and the subjects were divided into the control group and the observation group according to the random number table method, with 49 patients in each group. Patients in the control group were po administered with Bailing Capsules with warm water, 2.5 g/time, three times daily. Patients in the observation group were iv administered with Alprostadil injection on the basis of the control group, 2 mL of Alprostadil injection was added to 0.9% normal saline 20 mL, once per day. Both groups were treated continuously for 1 month. The clinical efficacy of the two groups was observed, and the renal function and inflammatory level of the two groups were compared before and after treatment. Results After treatment, the total effective rate of the control group and the observation group was 75.51% and 91.84%, respectively, and the total effective rate of the two groups was statistically different (P<0.05). After treatment, the levels of Scr, BUN, and Upro at 24 h were significantly decreased, and the evaluation value of eGFR was significantly increased (P<0.05), and the indexes of the observation group were significantly better than the control group (P<0.05). After treatment, the levels of serum TNF-α, hs-CRP and IL-18 in the two groups were significantly reduced, and the observation group was significantly lower than the control group (P<0.05). Conclusion Alprostadil combined with Bailing Capsules can effectively improve the renal function of patients with chronic kidney disease, regulate the immune system, and have a safe and significant effect, which is of positive significance for promoting the rehabilitation of patients with early chronic kidney disease.

R983

新疆維吾爾自治區(qū)自然科學(xué)基金聯(lián)合基金資助項(xiàng)目（2016D01C020）