[關(guān)鍵詞]
[摘要]
目的 研究云香十五味丸聯(lián)合塞來昔布膠囊對膝骨關(guān)節(jié)炎患者的臨床療效。方法 選擇2018年1月—2019年6月就診于鄂爾多斯市中心醫(yī)院的200例膝骨關(guān)節(jié)炎患者作為研究對象。對照組口服塞來昔布膠囊,0.2 g/次,1次/d。觀察組在對照組基礎(chǔ)上臨睡前口服云香十五味丸,10粒/次,1次/d。兩組均治療3個月。治療2周、1個月、3個月后,兩組患者VAS積分均明顯降低(P<0.05)。治療1個月后,治療組患者的VAS評分明顯低于對照組(P<0.05)。治療后,兩組患者不同時間疼痛程度、僵硬程度、生活困難程度積分及WOMAC總積分均明顯降低(P<0.05)。治療2周,觀察組患者晨起僵硬及WOMAC總積分明顯低于對照組;治療1個月,觀察組各項目積分及WOMAC總積分均明顯低于對照組(P<0.05)。治療3個月,TESS評分變化較小,差異不具有統(tǒng)計學(xué)意義。結(jié)論 云香十五味丸聯(lián)合塞來昔布膠囊能有效減輕膝骨關(guān)節(jié)炎患者疼痛,改善關(guān)節(jié)功能,具有一定的的臨床推廣價值。
[Key word]
[Abstract]
Objective To study the clinical effectiveness of Yunxiang Shiwu Pills combined with Celecoxib Capsules in treatment of knee osteoarthritis. Methods A total of 200 patients with knee osteoarthritis who visited Ordos Central Hospital from January 2018 to June 2019 were selected as the study subjects. Patients in the control group were po administered with Celecoxib Capsules, 0.2 g/time, once daily. Patients in the observation group were po administered Yunxiang Shiwu Pills on the basis of control group, 10 pills/time, once daily. Both groups were treated for 3 months. After treatment, the changes of VAS, WOMAC, and TESS between two groups of patients before and, 2 weeks, 1 month, and 3 months after treatment were compared. Results After 2 weeks, 1 month and 3 months of treatment, VAS scores of patients in two groups were significantly reduced (P<0.05). After 1 month of treatment, VAS score of patients in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the pain degree, stiffness degree, life difficulty score, and WOMAC total score of two groups were significantly reduced at different times (P<0.05). Two weeks after treatment, morning stiffness and WOMAC score in the observation group were significantly lower than those in the control group. One month after treatment, the scores of each item and WOMAC in the observation group were significantly lower than those in the control group (P<0.05). TESS score changed little after 3 months of treatment, and the difference was not statistically significant. Conclusion Yunxiang Shiwu Pills combined with Celecoxib Capsules can effectively alleviate the pain and improve the joint function of patients with knee osteoarthritis, which has certain clinical promotion value.
[中圖分類號]
R913
[基金項目]
鄂爾多斯市中心醫(yī)院院級課題(EY2017009)