目的 探討分析藍(lán)芩口服液聯(lián)合阿莫西林克拉維酸鉀分散片治療兒童急性扁桃體炎的療效及對(duì)患兒血清白細(xì)胞介素-2（IL-2）、白細(xì)胞介素-6（IL-6）、可溶性白細(xì)胞介素-2受體（sIL-2R）水平的影響。方法 選擇2017年1月—2018年7月北京市石景山區(qū)婦幼保健院收治的急性扁桃體炎患兒192例作為研究對(duì)象，將患兒隨機(jī)分為對(duì)照1組（n=63）、對(duì)照2組（n=64）和觀察組（n=65）。對(duì)照1組患兒給予阿莫西林克拉維酸鉀分散片，3~7歲患兒1片/次；8~12歲患兒1.5片/次；＞12歲患兒2片/次，3次/d。治療7 d為1個(gè)療程。對(duì)照2組患兒給予藍(lán)芩口服液，3~7歲患兒1支/次；8~12歲患兒，1.5支/次；＞12歲患兒2支/次，3次/d，治療7 d為1個(gè)療程。觀察組患兒的治療方案為藍(lán)芩口服液聯(lián)合阿莫西林克拉維酸鉀分散片，服用方案與對(duì)照組相同。治療7 d為1個(gè)療程。觀察3組患者的臨床療效、退熱時(shí)間、癥狀改善時(shí)間及復(fù)發(fā)率，同時(shí)比較3組治療前后的IL-2、IL-6及sIL-2R水平。結(jié)果 治療后，觀察組患兒臨床治療總有效率為95.38%，明顯高于對(duì)照1組的84.13%和對(duì)照2組的81.25%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組患兒退熱時(shí)間、癥狀改善時(shí)間及復(fù)發(fā)率均顯著低于對(duì)照1組和對(duì)照2組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；對(duì)照1組與對(duì)照2組在癥狀改善時(shí)間方面具有顯著性差異（P<0.05）。治療后，3組患兒血清IL-2、IL-6以及sIL-2R水平均較治療前顯著降低（P<0.05）；且治療后觀察組患兒血清IL-2、IL-6以及SIL-2水平顯著低于對(duì)照1組和對(duì)照2組，差異均具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 藍(lán)芩口服液聯(lián)合芩口服液和阿莫西林克拉維酸鉀治療急性扁桃體炎可有效促進(jìn)疾病恢復(fù)，改善機(jī)體免疫能力，值得臨床推廣。

Objective To investigate the effect of Lanqin Oral Liquid combined with Amoxicillin and Clavulanate Potassium Dispersible Tablets in treatment of acute tonsillitis in children and its effect on the serum levels of interleukin-2 (IL-2), interleukin-6 (IL-6) and soluble interleukin-2 receptor (SIL-2R) in children. Methods A total of 192 children with acute tonsillitis admitted to Maternal and Child Health Hospital of Shijingshan District from January 2017 to July 2018 were selected as the research objects and randomly divided into control group 1 (n=63), control group 2 (n=64) and observation group (n=65). Children in control group 1 were given Amoxicillin and Clavulanate Potassium Dispersible Tablets, 1 tablet/time for 3-7 years old children, 1.5 tablets/time for children aged 8-12 years, children older than 12 years old took 2 tablets/time, and the use frequency was three times daily. Children in control group 2 were given Lanqin Oral Liquid, 1 branch/time for 3-8 years old children, 1.5 branch/time for 8-12 years old children, children order than 12 years old took 2 branch/time, the use frequency was three times daily, and treatment duration was 7 days. The treatment regimen of the children in the observation group was Lanqin Oral Liquid combined with Amoxicillin and Clavulanate Potassium Dispersible Tablets, which was the same as that of the control group. One course of treatment lasted for 7 days. After treatment, the clinical efficacy, antifebrile duration, symptom improvement time, and recurrence rate of patients in the three groups were observed, and the levels of IL-2, IL-6 and SIL-2R in the three groups were compared before and after treatment. Results After treatment, the total effective rate of clinical treatment in the observation group was 95.38%, significantly higher than 84.13% in control group 1 and 81.25% in control group 2, with statistically significant difference (P<0.05). After treatment, the antifebrile time, symptom improvement time, and recurrence rate of the children in the observation group were significantly lower than those in the control group 1 and 2, with statistically significant differences (P<0.05). There was significant difference in symptom improvement time between control group 1 and control group 2 (P<0.05). After treatment, serum levels of IL-2, IL-6, and sIL-2R were significantly lower in the three groups than before treatment (P<0.05). Moreover, the serum levels of IL-2, IL-6 and sIL-2R in the observation group were significantly lower than those in the control group 1 and 2 after treatment, with statistically significant differences (P<0.05). Conclusion Lanqin oral liquid combined with Lanqin Oral Liquid combined with Amoxicillin and Clavulanate Potassium Dispersible Tablets in treatment of acute tonsillitis can effectively promote the recovery of disease and improve the immune ability of the body, which is worthy of clinical promotion.

R974