泊沙康唑作為第二代三唑類抗真菌藥物，其抗菌譜廣、抗菌作用強(qiáng)、耐受性好，因而受到臨床廣泛關(guān)注。泊沙康唑口服制劑達(dá)峰時(shí)間為3~5 h，血漿蛋白結(jié)合率高達(dá)98%，其體內(nèi)藥物代謝受食物、用藥方案、藥物相互作用等因素影響，導(dǎo)致個(gè)體間血漿藥物濃度變異性大，而泊沙康唑血漿藥物濃度與其臨床療效密切相關(guān)，故推薦臨床開展泊沙康唑治療藥物監(jiān)測(cè)，以保證其穩(wěn)態(tài)谷濃度大于有效濃度。目前常用于泊沙康唑濃度檢測(cè)的方法有微生物檢定法、化學(xué)熒光法及色譜法，其中液相色譜串聯(lián)質(zhì)譜法靈敏、準(zhǔn)確、簡單，為藥物濃度檢測(cè)“金標(biāo)準(zhǔn)”。

As a second generation of triazole antifungal drug, posaconazole has been widely used in clinic because of its wide antibacterial spectrum, strong antimicrobial activity and good tolerance. The t_max of posaconazole is 3-5 h, and the binding rate of plasma protein was up to 98%. However, the pharmacokinetics of posaconazole are easily affected by food, drug regimen, drug interaction and other factors, resulting in great variability of drug concentration in plasma among individuals, and drug concentration of posaconazole is closely related to its clinical efficacy. Therefore, it is recommended to carry out therapeutic drug monitoring of posaconazole. At present, the commonly used methods for the detection of posaconazole concentration include microbial assay, chemical fluorescence and chromatography. Among them, liquid chromatography tandem mass spectrometry is sensitive, accurate and simple, and is the "gold standard" for the detection of drug concentration.

R978.5

福建省臨床重點(diǎn)?？平ㄔO(shè)項(xiàng)目（閩衛(wèi)醫(yī)政函［2018］ 145號(hào)）；福州市衛(wèi)生健康科技創(chuàng)新平臺(tái)項(xiàng)目（2019-S-wp6）；福州市感染性疾病醫(yī)學(xué)中心科研項(xiàng)目（2018080306）