Ks)電流的影響。結(jié)果 色原烷醇293B可以顯著延長(zhǎng)50%和90%復(fù)極化動(dòng)作電位持續(xù)時(shí)間(APD50和APD90),0.01、0.10、1.00 mmol/L TMCC可以顯著減弱色原烷醇293B延長(zhǎng)APD50和APD90的作用(P<0.05、0.01)。TMCC (0.01、0.10、1.00 mmol/L)對(duì)抗色原烷醇293B對(duì)IKs電流的抑制作用,減弱色原烷醇293B對(duì)I-V曲線的下移,0.1、1.0 mmol/L濃度組顯著減弱色原烷醇293B對(duì)IKs電流的抑制作用(P<0.01),呈現(xiàn)對(duì)抗LQTS的作用。結(jié)論 TMCC通過(guò)縮短動(dòng)作電位復(fù)極時(shí)程,增大被抑制的IKs電流,發(fā)揮一定的抗LQTS的作用。;objective The anti-arrhythmic effect of Taurine-Magnesium Coordination Compound (TMCC) was assessed on the model of long QT syndrome (LQTS). Methods Chromanol 293B (5 μmol/L) was used to establish the LQTS model in guinea pig ventricular myocytes and to inhibit HEK293 cells stably expressing IKs channels. All cells were incubated for 24 h in the absence and presence of drugs. The IKs current and action potentials were recorded by using the whole-cell patch-clamp technique. Results Chromanol 293B significantly prolonged APD50 and APD90 (P<0.01). TMCC could attenuate the effect of chromanol 293B on prolongation APD50 and APD90, which could be reversed significantly by TMCC (0.01, 0.1, 1.0 mmol/L) (P<0.05 and 0.01). TMCC (0.01, 0.1, and 1 mmol/L) were concentration-dependently against the effect of chromanol 293B on IKs current inhibition. The IKs I-V curve was shifted downwards by chromanol 293B (5 μmol/L), while upwards by TMCC. TMCC (0.01, 0.10, and 1.00 mmol/L) could restore the decrease of peak IKs due to chromanol 293B (P<0.01). Conclusion It was suggested that TMCC have antiarrhythmic effect on LQTS through shortening the action potential duration and increasing the inhibited IKs current."/> Ks;chromanol 293B"/>