目的 探討復方蓯蓉益智膠囊治療帕金森病肝腎虧虛型失眠患者的臨床療效。方法 選取2019年1月-2020年6月長沙市第四醫(yī)院帕金森疾病肝腎虧虛證型失眠患者60例作為研究對象，根據(jù)治療方法將患者分為對照組和觀察組，每組30例。對照組口服阿普唑侖片，0.4 mg/次，3次/d。觀察組患者口服復方蓯蓉益智膠囊，4粒/次，3次/d。兩組均服用2周。觀察兩組患者的臨床療效和匹茲堡睡眠質(zhì)量評分（PSQI），同時比較兩組患者的焦慮自評量表（SAS）、抑郁自評量表（SDS）、Barthel指數(shù)（BI）。結(jié)果 治療后，觀察組總有效率為86.70%，與對照組的90.00%相比，差異無統(tǒng)計學意義。治療后，觀察組的睡眠障礙評分、睡眠時間及日間功能評分均優(yōu)于對照組（P<0.05）。治療后，兩組SAS、SDS評分均顯著降低，觀察組BI評分顯著升高（P<0.05）；治療后，觀察組SDS評分顯著低于對照組，BI評分高于對照組（P<0.05）。結(jié)論 復方蓯蓉益智膠囊治療帕金森病肝腎虧虛型失眠患者可有效改善睡眠質(zhì)量，臨床療效顯著。

Objective To investigate the clinical effect of Compound Congrong Yizhi Capsules in treatment of insomnia of liver and kidney deficiency in Parkinson's disease. Methods A total of 60 cases patients with Parkinson's disease insomnia of liver and kidney deficiency syndrome in The Fourth Hospital of Changsha from January 2019 to June 2020 were selected as the research subjects. According to the treatment methods, the patients were divided into control group and observation group, with 30 cases in each group. Patients in the control group were po administered with Alprazolam Tablets, 0.4 mg/time, three times daily. Patients in the observation group were po administered with Compound Congrong Yizhi Capsules, 4 capsules/time, three times daily. Both groups were treated for 2 weeks. Clinical efficacy and PSQI score of two groups were observed, and the SAS, SDS, BI score and motor dysfunction score of two groups were compared. Results After treatment, the total effective rate of the observation group was 86.70%, compared with 90.00% of the control group, and the difference was not statistically significant. After treatment, the sleep disorder score, sleep time and daytime function score in observation group were better than those in control group (P<0.05). After treatment, SAS and SDS scores of two groups were significantly decreased, while BI score of the observation group was significantly increased (P<0.05). After treatment, SDS score was significantly lower than control group, BI score was higher than control group (P<0.05). Conclusion Compound Congrong Yizhi Capsules can effectively improve sleep quality in patients with insomnia of liver and kidney deficiency in Parkinson's disease with significant clinical effect.

R971