目的 系統(tǒng)評(píng)價(jià)戊乙奎醚預(yù)防剖宮產(chǎn)術(shù)應(yīng)用卡前列素氨丁三醇所引發(fā)的不良反應(yīng)。方法 計(jì)算機(jī)檢索PubMed、Embase、Cochrane圖書館、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)（CBM）、中國(guó)學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)（CNKI）、維普中文期刊全文數(shù)據(jù)庫(kù)（VIP）和萬(wàn)方數(shù)據(jù)庫(kù)，檢索時(shí)限均為建庫(kù)起至2020年5月，收集戊乙奎醚降低卡前列素氨丁三醇在剖宮產(chǎn)術(shù)中不良反應(yīng)的隨機(jī)對(duì)照研究（RCT），采用RevMan 5.3統(tǒng)計(jì)軟件對(duì)惡心、嘔吐、面部潮紅、胸悶氣短、心悸、腹痛及血壓升高等不良反應(yīng)發(fā)生率進(jìn)行Meta分析。結(jié)果 共納入13個(gè)RCTs，1 027例患者。Meta分析結(jié)果顯示：戊乙奎醚組惡心發(fā)生率[RR=0.36，95% CI=0.29~0.45，P<0.01]、嘔吐發(fā)生率[RR=0.21，95% CI=0.15~0.30，P<0.01]、面部潮紅發(fā)生率[RR=0.37，95% CI=0.26~0.52，P<0.01]、胸悶氣短發(fā)生率[RR=0.32，95% CI=0.26~0.40，P<0.01]、心悸發(fā)生率[RR=0.38，95% CI=0.28~0.50，P<0.01]、腹痛發(fā)生率[RR=0.52，95% CI=0.35~0.76，P<0.01]和血壓升高發(fā)生率[RR=0.43，95% CI=0.22~0.85，P=0.02]均顯著低于對(duì)照組。結(jié)論 戊乙奎醚能顯著降低卡前列素氨丁三醇致惡心、嘔吐、面部潮紅、胸悶氣短、心悸、腹痛及血壓升高等不良反應(yīng)的發(fā)生。

Objective To systematically evaluate penehyclidine to reduce the adverse effects of carprostamine trometamol during cesarean section. Methods Retrieved from PubMed, Embase, Cochrane library, CBM, CNKI, VIP and Wanfang database, randomized controlled trials (RCTs) about the penehyclidine to reduce the adverse effects of carprostamine trometamol during cesarean section were collected during database establishment to May 2020. Meta-analysis was performed for the incidence of nausea, vomiting, facial flushing, chest tightness, shortness of breath, palpitations, abdominal pain and increased blood pressure by using Rev Man 5.3 statistical software. Results A total of 13 RCTs were included, involving 1 027 patients. Meta-analysis showed that the penehyclidine group in the incidence of nausea in[RR=0.36, 95%CI=0.29 to 0.45, P<0.01], the incidence of vomiting[RR=0.21, 95%CI=0.15 to 0.30, P<0.01], the incidence of facial flushing[RR=0.37, 95%CI=0.26 to 0.52, P<0.01], incidence of chest tightness[RR=0.32, 95%CI=0.26 to 0.40, P<0.01], incidence of heart palpitations[RR=0.38, 95%CI=0.28 to 0.50, P<0.01], incidence of abdominal pain[RR=0.52, 95%CI=0.35 to 0.76, P<0.01] and incidence of high blood pressure[RR=0.43, 95%CI=0.22 to 0.85, P=0.02] significantly lower than the control group. Conclusion The results of this study shows that penehyclidine can significantly reduce the incidence of nausea, vomiting, facial flushing, chest tightness, palpitations, abdominal pain and increased blood pressure caused by carprostamine trometamol.

R984

河北省科技計(jì)劃資助項(xiàng)目（172777108D）