α-葡萄糖苷酶抑制劑能有效降低餐后血糖，為臨床一線降糖用藥之一。近年來報道了大量新化合物作為α-葡萄糖苷酶抑制劑，不僅可以起到降糖的作用，而且還具有抗溶酶體堆積病、抗病毒、抗菌和抗癌的藥效。α-葡萄糖苷酶抑制劑新型化合物按照產(chǎn)出途徑主要有微生物代謝產(chǎn)物、天然產(chǎn)物與化學(xué)合成產(chǎn)物。就近年來開發(fā)的多種類型的α-葡萄糖苷酶抑制劑及其抗癌、抗病毒和抗溶酶體堆積病作用進行了綜述，旨在為α-葡萄糖苷酶抑制劑或臨床前候選藥物提供更好的研究方向。

Alpha-glucosidase inhibitor is one of the first-line antidiabetic medication which could reduce postprandial blood glucose effectively. In recent years, a substantial number of new compounds have been reported as alpha-glucosidase inhibitors, have multiple physiological effects including hypoglycemic effects, anticancer, antiviral, and anti-lysosomal storage disorders effect. The main types of new alpha-glucosidase inhibitor are microbial metabolites, natural products and chemically synthesized products. This review presents the various types of alpha-glucosidase inhibitors developed in recent years and its pharmacological effects, aimed to provide guidance to alpha-glucosidase inhibitors or clinical candidates.

R977.1

國家自然基金青年科學(xué)基金資助項目（81302841）；遼寧省高等學(xué)校優(yōu)秀人才支持計劃（LJQ2014086）