貓爪草Ranunculus ternatus Thunb.作為一種天然低毒的抗腫瘤藥物受到重視，對(duì)其提取部位及有效成分抗腫瘤機(jī)制形成了一定認(rèn)識(shí)。藥理研究發(fā)現(xiàn)貓爪草的主要化學(xué)成分為皂苷類(lèi)、脂肪酸類(lèi)、多糖類(lèi)、醇及酯類(lèi)、揮發(fā)油類(lèi)、黃酮類(lèi)、生物堿及微量元素等成分，其中皂苷類(lèi)、多糖類(lèi)、脂肪酸類(lèi)、醇及酯類(lèi)是其重要的抗腫瘤活性成分，其抗腫瘤的主要機(jī)制有調(diào)節(jié)機(jī)體免疫功能、抑制腫瘤生長(zhǎng)增殖、誘導(dǎo)腫瘤細(xì)胞凋亡、減少氧化應(yīng)激損傷。在肝癌、肺癌、乳腺癌、結(jié)腸癌、甲狀腺癌、惡性淋巴瘤、子宮肌瘤的防治過(guò)程中，具有多成分、多途徑、多效應(yīng)的特點(diǎn)。對(duì)貓爪草在抗腫瘤治療中的有效成分及作用機(jī)制作一概述，為進(jìn)一步完善抗腫瘤研究以及新劑型開(kāi)發(fā)與臨床利用提供依據(jù)。

As a natural and low-toxic anti-tumor drug, Ranunculus ternatus has been paid attention to, and a certain understanding of its extracted parts and anti-tumor mechanism of its active components has been formed. Pharmacological studies have found that the main chemical components are saponins, fatty acids, polysaccharides, alcohols and esters, volatile oils, flavonoids, alkaloids and trace elements, among which saponins, polysaccharides, fatty acids, alcohols and esters are important anti-tumor components. The main mechanisms of its anti-tumor are regulating immune function, inhibiting tumor growth and proliferation, inducing tumor cell apoptosis and reducing oxidative stress injury. It has the characteristics of multi-component, multi-pathway and multi-effect in the prevention and treatment of liver cancer, lung cancer, breast cancer, colon cancer, thyroid cancer, malignant lymphoma and uterine leiomyoma. This paper summarizes the effective components and mechanism of the traditional Chinese medicine Ranunculus ternatus in anti-tumor therapy, in order to provide a basis for further improving the anti-tumor research,development and clinical utilization of new dosage forms.

R285.5

天津市科委慢病防治重大專(zhuān)項(xiàng)（17ZXMFSY00190）