目的 觀察香砂平胃顆粒聯(lián)合伊托必利治療功能性消化不良的臨床效果。方法 選取2018年6月-2019年6月在重慶市巴南區(qū)人民醫(yī)院進(jìn)行治療的功能性消化不良患者83例作為研究對象，根據(jù)治療方法將患者分為對照組（41例）和觀察組（42例）。對照組患者口服鹽酸伊托必利分散片，50 mg/次，3次/d；觀察組在對照組的基礎(chǔ)上口服香砂平胃顆粒，1袋/次，2次/d。兩組患者均治療30 d。觀察兩組患者的臨床療效，同時比較兩組治療前后的胃腸激素水平、電節(jié)律情況、生活質(zhì)量和臨床積分。結(jié)果 治療后，觀察組總有效率為97.6%，顯著高于對照組的65.8%，兩組總有效率比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者血清胃動素（MTL）、胃泌素（GAS）和P物質(zhì)（SP）水平均明顯升高（P<0.05），且觀察組患者胃腸激素水平顯著高于對照組（P<0.05）。治療后，兩組患者的胃體、胃大彎、胃小彎、胃竇電節(jié)律均明顯降低（P<0.05）；觀察組患者電節(jié)律顯著低于對照組（P<0.05）。治療后，兩組患者SF-36評分均顯著提高（P<0.05），且觀察組SF-36評分顯著高于對照組（P<0.05）。治療后，兩組患者在飽脹感、早飽、上腹痛、胃灼熱感評分及總分均顯著降低（P<0.05）；且觀察組臨床癥狀評分顯著低于對照組（P<0.05）。結(jié)論 香砂平胃顆粒聯(lián)合伊托必利治療功能性消化不良患者療效顯著，能改善臨床癥狀，提高患者胃動力功能和生活質(zhì)量，值得推廣使用。

Objective To observe the clinical effect of Xiangsha Pingwei Granules combined with itopride in treatment of functional dyspepsia. Methods A total of 83 patients with functional dyspepsia treated in People's Hospital of Chongqing Banan District from June 2018 to June 2019 were selected as the research subjects, and the patients were divided into control group (41 cases) and observation group (42 cases) according to the treatment methods. Patients in the control group were po administered with Itopride Hydrochloride Dispersible Tablets, 50 mg/time, three times daily. Patients in the observation group were po administered with Xiangsha Pingwei Granules on the basis of control group, 1 bag/time, twice daily. Patients in two groups were treated for 30 d. The clinical efficacy of two groups was observed, and the levels of gastrointestinal hormones, electrical rhythm, quality of life and clinical scores of the two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 97.6%, which was significantly higher than 65.8% of the control group, and the difference between two groups was statistically significant (P < 0.05). After treatment, the serum levels of MTL, GAS, SP in two groups were significantly increased (P < 0.05), and the gastrointestinal hormone level in observation group was significantly higher than those in control group (P < 0.05). After treatment, the gastric body, greater curvature, lesser curvature, and antrum of the stomach electric rhythm in two groups were significantly decreased (P < 0.05), and the electric rhythm in observation group was significantly lower than that in control group (P < 0.05). After treatment, the SF-36 score in two groups was significantly increased (P < 0.05), and the observation group was significantly higher than the control group (P < 0.05). After treatment, the scores of feeling of fullness, early satiety, epigastric pain, heartburn and total scores in two groups were significantly decreased (P < 0.05), and the clinical symptom score of observation group was significantly lower than those of control group (P < 0.05). Conclusion Xiangsha Pingwei Granules combined with itopride has significant efficacy in treatment of patients with functional dyspepsia, which can improve clinical symptoms, improve gastric motility function and quality of life of patients, and is worthy of promotion.

R975

重慶市衛(wèi)計(jì)委醫(yī)學(xué)科研課題（2017ZDXM006）