茵陳蒿湯源自《傷寒論》，為治療濕熱黃疸的經(jīng)典方劑。藥理研究發(fā)現(xiàn)其對(duì)多種類型肝損傷具有保護(hù)作用，可用于膽汁淤積、非酒精性脂肪肝、酒精性脂肪肝、肝纖維化、肝硬化的治療，肝保護(hù)機(jī)制為調(diào)節(jié)膽紅素膽汁酸代謝、降脂降糖、抗氧化、抑制肝星狀細(xì)胞增殖和活化、抑制肝細(xì)胞凋亡、抗炎、調(diào)節(jié)腸道菌群。對(duì)茵陳蒿湯的藥動(dòng)學(xué)研究日漸增多，肝損傷對(duì)其藥動(dòng)學(xué)行為產(chǎn)生一定影響。綜述茵陳蒿湯在肝臟疾病防治中的藥理作用和藥動(dòng)學(xué)特征，為該方劑的開發(fā)應(yīng)用和臨床合理使用提供依據(jù)。

Yinchenhao Decotion is originally described in shanghanlun, which is a classic prescription for the treatment of damp and hot jaundice. It has been confirmed for the therapeutic effects in various liver injuries, including cholestasis, nonalcoholic fatty liver, alcoholic fatty liver, liver fibrosis, cirrhosis. The hepatoprotective mechanism is related to the regulation of bile acid and bilirubin metabolism, lipid and glucose lowering, anti-oxidation, inhibition of activation and proliferation of hepatic stellate cells, inhibition of apoptosis of hepatic cells, anti-inflammatory and regulation of intestinal flora. Studies on the pharmacokinetics of Yinchenhao Decotion are increasing, and liver injury may influence its pharmacokinetic behavior. This review aims to summarize the pharmacological mechanism and pharmacokinetic characteristics of Yinchenhao Decotion in the prevention and treatment of liver diseases, so as to provide a basis for its further exploration and clinical application.

R951

國(guó)家自然科學(xué)基金資助項(xiàng)目（82004049），南京藥學(xué)會(huì)—常州四藥醫(yī)院藥學(xué)科研基金資助項(xiàng)目（2018YX001），江蘇省藥學(xué)會(huì)—奧賽康醫(yī)院藥學(xué)基金資助項(xiàng)目（A201808），南京市中醫(yī)院科研基金項(xiàng)目（YJJC201901），南京市中醫(yī)藥青年人才培養(yǎng)計(jì)劃（ZYQ20019）