Ames試驗(yàn)是一項(xiàng)體外致突變性試驗(yàn)，被廣泛用于藥物、食品、化學(xué)品和農(nóng)藥的遺傳毒性檢測(cè)，以評(píng)價(jià)受試物致突變的可能性。藥物、食品、化學(xué)品和農(nóng)藥的指導(dǎo)原則和國(guó)家標(biāo)準(zhǔn)中Ames試驗(yàn)方法不盡相同，就這幾者Ames試驗(yàn)方法的主要異同點(diǎn)進(jìn)行比較分析，以期能熟練掌握Ames試驗(yàn)實(shí)施要點(diǎn)，更加規(guī)范實(shí)施檢測(cè)工作，不斷提高試驗(yàn)質(zhì)量。

Ames test is a mutagenicity test in vitro, which is widely used in the detection of genotoxicity of drugs, food, chemicals and pesticides to evaluate the possibility of mutagenicity of test substance. The guiding principles and national standards of Ames test on drugs, food, chemicals and pesticidesand are different. In this paper, the main similarities and differences were compared and analyzed in order to master the key points of Ames test implementation, so we can implement the testing work standardly and improve the test quality constantly.

R962.2

山東省創(chuàng)新公共服務(wù)平臺(tái)項(xiàng)目（2015CXPT00001）