催產(chǎn)素是由下丘腦合成的一種神經(jīng)肽，在分娩時(shí)促進(jìn)子宮平滑肌的收縮，但其在社交行為、焦慮、情緒、疼痛調(diào)節(jié)等方面也起重要作用。催產(chǎn)素通過(guò)外周和中樞多種藥理機(jī)制參與鎮(zhèn)痛和抗焦慮的作用已得到廣泛研究。綜述了近年來(lái)催產(chǎn)素與疼痛和焦慮相關(guān)的基礎(chǔ)和臨床研究進(jìn)展，總結(jié)相關(guān)作用機(jī)制，并進(jìn)一步探討了催產(chǎn)素參與的鎮(zhèn)痛和抗焦慮間的聯(lián)系，有助于深入了解其多重作用機(jī)制，為這些疾病的治療及新藥研發(fā)提供依據(jù)。

Oxytocin is neuropeptide synthesized by the hypothalamus, of which classical physiological function is to promote contraction of smooth, but recent studies have demonstrated that oxytocin plays an important role in social behavior, anxiety, mood and pain. The effects of oxytocin on analgesia and anti-anxiety by acting in the central and peripheral nervous system have been extensively studied. This article reviewed recent advances in research on basic and clinical works, summarized corresponding mechanisms and discussed the relationships between analgesia and anti-anxiety induced by oxytocin, which may help understand the multiple function of oxytocin and provide insights for the application and development of new drug.

R984

上海市科委醫(yī)學(xué)引導(dǎo)類項(xiàng)目（19401930500）；上海市衛(wèi)健委面上項(xiàng)目（201740072）