氧化苦參堿對(duì)心臟具有正性肌力和負(fù)性頻率作用，對(duì)心肌自律性：在低濃度時(shí)降低、高濃度時(shí)提高自律性。氧化苦參堿能顯著降低變?yōu)槁磻?yīng)細(xì)胞的心室肌的自律性。其正性肌力作用的機(jī)制系促進(jìn)外鈣內(nèi)流，從而促進(jìn)心肌細(xì)胞內(nèi)的肌漿網(wǎng)鈣大量釋放所致。而負(fù)性自律性和負(fù)性頻率產(chǎn)生的機(jī)制與阻滯鈉離子通道有關(guān)。因此氧化苦參堿能防治心力衰竭、心肌缺血和各種化學(xué)品引起的心律失常。

Matrine has positive inotropic action and negative chronotropic action,and in myocardial automaticity low concentration decreasing and high concentration increasing automaticity. Oxymatrine decreases myocardial automaticity of becoming slow response cells. The mechanisms of positive inotropic action is promoting extracellular calcium to flow into intracellular. thus promoting Ca²⁺ release of sarcoplasmic reticulum in myocardium. The mechanism of negative automaticity and negative chronotropic action may relate to blocking Na+ channel, oxymatrine can prevent and treat arrhythmia induced by heart failure, myocardial ischemia, and various chemicals.

R285.5