目的 系統(tǒng)性評價冠狀動脈內(nèi)注射尼可地爾治療ST段抬高心肌梗死（STEMI）的臨床及預后效果。方法 計算機檢索中國學術(shù)期刊全文數(shù)據(jù)庫（CNKI）、萬方數(shù)據(jù)知識服務平臺（Wanfang Data）、維普期刊中文數(shù)據(jù)庫（VIP）、中國生物醫(yī)學文獻數(shù)據(jù)庫（CBM）、Web of Science、Wiley Online Library、Embase和PubMed數(shù)據(jù)庫，納入冠狀動脈內(nèi)注射尼可地爾治療STEMI的隨機對照臨床試驗研究（RCTs），檢索時間為建庫至2020年10月。采用Revman 5.3評價納入研究的方法學質(zhì)量，Stata 12.0軟件進行Meta分析。結(jié)果 共納入12篇RCTs，934名患者。Meta分析結(jié)果顯示：試驗組治療STEMI患者術(shù)后TIMI血流分級≤2發(fā)生率［OR=0.53，95% CI=（0.4，0.71）］、校正TIMI幀數(shù)［WMD=-8.93，95% CI=（-13.18，-4.67）］、左室射血分數(shù)［SMD=0.65，95% CI=（0.42，0.88）］、左室舒張末期內(nèi)徑［WMD=-5.56，95% CI=（-7.75，-3.38）］、主要不良心血管事件［OR=0.54，95% CI=（0.4，0.72）］、再灌注心律失常［OR=0.55，95% CI=（0.33，0.91）］、心力衰竭發(fā)生情況［OR=0.4，95% CI=（0.19，0.86）］均顯著小于對照組（P<0.05）。結(jié)論 現(xiàn)有的臨床證據(jù)表明接受PCI的STEMI患者手術(shù)期間冠狀動脈內(nèi)單獨注射尼可地爾能改善患者冠脈血流量，保留患者的心臟收縮功能，還可以降低主要不良心血管事件的發(fā)生率。

Objective To systematically evaluate the clinical and prognostic effects of intracoronary injection of nicorandil in the treatment of ST segment elevation myocardial infarction (STEMI). Methods Full-text Database of CNKI, Wanfang Data, VIP, CBM, Web of Science、Wiley Online Library、Embase and PubMed databases were searched by computer from the establishment of the database to October 2020. Revman 5.3 was used to evaluate the quality of the methodology included in the study, and Stata12.0 software was used for Meta-analysis. Results A total of 12 articles of RCTs and 934 patients were included. The results of Meta analysis showed that the incidence of TIMI flow grade ≤ 2 in patients with STEMI after treatment in the trial group[OR = 0.53, 95%CI = (0.4, 0.71)], corrected TIMI frames [WMD = -8.93, 95%CI = (-13.18, -4.67)], left ventricular ejection fraction [SMD = 0.65, 95%CI = (0.42, 0.88)], left ventricular end-diastolic dimension [WMD = -5.56, 95%CI = (-7.75, -3.38) ], the main adverse cardiovascular events [OR = 0.54, 95%CI = (0.4, 0.72) ], reperfusion arrhythmias [OR = 0.55, 95%CI = (0.33, 0.91) ], heart failure[OR = 0.4, 95%CI = (0.19, 0.86) ] were significantly lower than those in the control group (P < 0.05). Conclusion Existing clinical evidence shows that intracoronary injection of nicorandil alone during PCI can improve coronary blood flow, preserve cardiac systolic function, and reduce the incidence of major adverse cardiovascular events in STEMI patients.

R972

國家自然科學基金資助項目（81303243）；陜西秦嶺中草藥應用開發(fā)工程技術(shù)研究中心資助項目（2008ZDGC-32）