細(xì)胞焦亡是近年來(lái)證實(shí)的一種新的程序性細(xì)胞死亡方式，由消化道皮膚素介導(dǎo)，表現(xiàn)為細(xì)胞不斷脹大直至細(xì)胞膜破裂，導(dǎo)致細(xì)胞內(nèi)容物的釋放進(jìn)而激活強(qiáng)烈的炎癥反應(yīng)，導(dǎo)致細(xì)胞程序性壞死。細(xì)胞焦亡的主要通路包含依賴半胱天冬氨酸蛋白酶（caspase）-1的經(jīng)典通路和依賴caspase-4、5、11的非經(jīng)典通路。細(xì)胞焦亡在原發(fā)性肝癌的癌前病變以及發(fā)展過(guò)程中起重要作用，歸納總結(jié)了細(xì)胞焦亡的分子機(jī)制及其在原發(fā)性肝癌治療中的研究進(jìn)展，以期為原發(fā)性肝癌的診斷、治療以及新藥研發(fā)提供新的依據(jù)。

Pyroptosis is a new type of programmed cell death that has been confirmed in recent years. It is mediated by digestive tract dermatans, which manifests itself as the continuous expansion of cells until the cell membrane ruptures, leading to the release of cell contents and activating a strong inflammatory response. Lead to programmed cell necrosis. The main pathways of pyroptosis include the classical pathways dependent on caspase-1 and the non-classical pathways dependent on caspase-4, 5, and 11. Cell pyroptosis plays an important role in the precancerous lesions and development of primary liver cancer. The molecular mechanism of pyroptosis and its research progress in the treatment of primary liver cancer are summarized, with a view to the diagnosis of primary liver cancer, treatment and new drug development to provide new basis.

國(guó)家自然科學(xué)基金資助項(xiàng)目（81774132）