氧化苦參堿能對抗缺氧、高糖和細(xì)菌毒素對血管內(nèi)皮細(xì)胞的損傷，抑制血管內(nèi)皮-間質(zhì)轉(zhuǎn)化，也能對抗低氧、轉(zhuǎn)化生長因子-β（TGF-β）、高血脂誘導(dǎo)血管平滑肌細(xì)胞增殖以及β-甘油磷酸鹽對血管平滑肌細(xì)胞的損傷，從而產(chǎn)生血管保護(hù)作用和改善血管功能。氧化苦參堿能擴(kuò)張血管和對抗高糖高脂、苯腎上腺素對血管的攣縮作用；可通過神經(jīng)節(jié)阻斷和促進(jìn)一氧化氮合成和釋放，產(chǎn)生降壓作用，也能通過改善心功能調(diào)節(jié)血壓；能抑制大鼠因缺氧或野百合堿引起的肺動(dòng)脈高壓和肺血管重構(gòu)以及高脂飲食引起的動(dòng)脈粥樣硬化。

Oxymatrine antagonizes hypoxia, hyper-glucose, and bacteriotoxin-induced vascular endothelial cells injuries, and inhibits vascular endothelial-mesenchymal transition, and antagonizes the proliferation of vascular smooth muscle cells induced by hypoxia, TGF-β and hyperlipemia, and β-glycerophosphate-induced vascular smooth muscle cells injuries, thus produces vascular protection and improves vascular function. Oxymatrine dilates blood vessel and antagonizes vascular contraction induced by hyperglycemia and hyperlipemia, or phenylephrine. Oxymatrine produces hypotension by blocking neuroganglion, and promoting the synthesis and secretion of NO, and regulates blood pressue by improving cardiac function too. Oxymatrine relieves pulmonary hypertension and pulmonary arterial modeling induced by hypoxia or monocrotaline, and hyperliposis diet-induced atherosclerosis in rats.