蛋白多肽類藥物脂質(zhì)體是將蛋白多肽類藥物用脂質(zhì)體包封后形成的載藥脂質(zhì)體，具有靶向、緩釋、良好的穩(wěn)定性等優(yōu)點。綜述了2000年以來中國專利申請中涉及的新型蛋白多肽類藥物脂質(zhì)體，包括凝膠型脂質(zhì)體、前體脂質(zhì)體、長循環(huán)脂質(zhì)體、免疫脂質(zhì)體、柔性脂質(zhì)體、pH敏感脂質(zhì)體、配體修飾脂質(zhì)體、磁性納米脂質(zhì)體、多囊脂質(zhì)體，為繼續(xù)開發(fā)新型的蛋白多肽類藥物脂質(zhì)體提供新的思路。

Protein polypeptide drug liposome are drug-loaded liposome formed by encapsulating protein polypeptide drug in liposome, which has the advantages of targeting, sustained release and good stability. The novel protein polypeptide drug liposome involved in Chinese patent applications including gel-type liposome, proliposome, long-circulating liposome, immunoliposome, flexible liposome, pH-sensitive liposome, ligand-modified liposome, magnetic nano-liposome, multivesicular liposome since 2000 were reviewed, in order to provide new ideas for the development of protein polypeptide drug liposome.