[關(guān)鍵詞]
[摘要]
目的 探討骨康膠囊聯(lián)合氨基葡萄糖膠囊治療脛骨平臺骨折的臨床療效。方法 選取2019年2月—2021年1月在廣西北海市第二人民醫(yī)院就診的80例脛骨平臺骨折患者作為研究對象,按照治療方法將80例患者分為對照組和觀察組,各包括40例。對照組口服氨基葡萄糖膠囊,0.75 g/次,2次/d。觀察組在對照組的基礎(chǔ)上口服骨康膠囊,1.6 g/次,3次/d。兩組連續(xù)治療6個月。觀察兩組的臨床療效、骨折愈合時間和完全負重時間,同時比較兩組治療前后的血清中β-膠原降解產(chǎn)物(β-CTX)、骨鈣素(BGP)、骨特異性堿性磷酸酶(BALP)的水平,以及視覺模擬評分法(VAS)、Lysholm功能量表評分情況。結(jié)果 治療后,觀察組的總有效率為92.50%,對照組為75.00%,組間比較有明顯差異(P<0.05)。治療后,兩組β-CTX、BGP、BALP水平均顯著升高(P<0.05);治療后,觀察組的β-CTX、BGP、BALP水平顯著高于對照組,差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組VAS評分顯著降低,Lysholm評分明顯升高(P<0.05);且治療后,觀察組VAS評分顯著低于對照組,Lysholm評分高于對照組(P<0.05)。治療后,觀察組的骨折愈合時間、完全負重時間均短于對照組,差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 骨康膠囊聯(lián)合氨基葡萄糖膠囊可促進脛骨平臺骨折術(shù)后的骨折愈合,改善膝關(guān)節(jié)功能,減輕疼痛程度,可能與調(diào)節(jié)骨代謝指標(biāo)有關(guān),具有良好臨床意義。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Gukang Capsules combined with Glucosamine Capsules in treatment of tibial plateau fracture. Methods Eighty patients with tibial plateau fracture treated in the Guangxi Beihai Second People's Hospital from February 2019 to January 2021 were selected as the research subjects. According to the treatment methods, the 80 patients were divided into control group and observation group, including 40 patients in each group. Patients in the control group were po administered with Glucosamine Capsules, 0.75 g/time, twice daily. Patients in the observation group were po administered with Gukang Capsules on the basis of control group, 1.6 g/time, three times daily. The two groups were treated for 6 months. Clinical efficacy, fracture healing time, and full weight bearing time of two groups were observed. Serum levels of β-CTX, BGP, and BALP, the scores of VAS and Lysholm functional scale were compared before and after treatment between two groups. After treatment, the total effective rate of the observation group was 92.50%, and that of the control group was 75.00%, there was a significant difference between groups (P < 0.05). After treatment, the levels of β-CTX, BGP and BALP in two groups were significantly increased (P < 0.05). After treatment, the levels of β-CTX, BGP, and BALP in the observation group were significantly higher than those in the control group, with statistical significance (P < 0.05). After treatment, VAS score in two groups was significantly decreased, while Lysholm score was significantly increased (P < 0.05). After treatment, the VAS score in the observation group was significantly lower than that in the control group, and the Lysholm score was higher than that in the control group (P < 0.05). After treatment, the fracture healing time and full weight bearing time in the observation group were shorter than those in the control group, with statistical significance (P < 0.05). Conclusion Gukang Capsules combined with Glucosamine Capsules can promote postoperative fracture healing of tibial plateau fracture, improve knee function and relieve pain, which may be related to the regulation of bone metabolism indexes, and has good clinical significance.
[中圖分類號]
R977
[基金項目]
北海市科學(xué)研究與技術(shù)開發(fā)計劃項目(201745B1301245000)