目的 探討丹參注射液聯(lián)合生長抑素治療急性胰腺炎的臨床療效。方法 選取2018年1月—2021年2月阜陽市人民醫(yī)院收治的94例急性胰腺炎患者作為研究對(duì)象，根據(jù)治療方法患者分為對(duì)照組和觀察組，每組各47例。對(duì)照組靜脈滴注注射用生長抑素，0.25 mg加入500 mL的生理鹽水充分稀釋，以250 μg/h速度進(jìn)行滴注，1次/d。觀察組在對(duì)照組基礎(chǔ)上靜脈滴注丹參注射液，20 mL加入250 mL的生理鹽水充分稀釋后靜脈滴注，1次/d。兩組均連續(xù)治療7 d。觀察兩組患者的臨床療效、癥狀和體征恢復(fù)時(shí)間，同時(shí)比較兩組治療前后的血清C反應(yīng)蛋白（CRP）、人巨噬細(xì)胞趨化蛋白-1（MCP-1）、中性粒細(xì)胞/淋巴細(xì)胞比值（NLR）和淀粉酶的水平及血液流變學(xué)指標(biāo)水平。結(jié)果 治療后，觀察組患者總有效率為95.74%，明顯高于對(duì)照組的82.98%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組淀粉酶、電解質(zhì)恢復(fù)時(shí)間、腹痛消失時(shí)間、腹脹消失時(shí)間均較對(duì)照組短，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的CRP、MCP-1、NLR、血清淀粉酶水平均顯著降低（P<0.05）；治療后，觀察組的CRP、MCP-1、NLR、淀粉酶水平顯著低于對(duì)照組（P<0.05）。治療后，兩組的全血高切黏度、血漿比黏度、血小板聚集率顯著下降（P<0.05）；且觀察組各項(xiàng)血液流變學(xué)指標(biāo)均低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 丹參注射液聯(lián)合生長抑素治療急性胰腺炎的療效確切，能進(jìn)一步減輕臨床癥狀，減輕炎癥反應(yīng)和改善血液流變學(xué)，安全性良好。

Objective To investigate the clinical efficacy of Danshen Injection combined with somatostatin in treatment of acute pancreatitis. Methods A total of 94 patients with acute pancreatitis admitted to Fuyang People's Hospital from January 2018 to February 2021 were selected as the research subjects. According to the treatment methods, the patients were divided into control group and observation group, with 47 patients in each group. Patients in the control group were iv administered with Somatostatin for Injection, 0.25 mg of which was fully diluted with 500 mL of normal saline, at the rate of 250 μg/h, once daily. Patients in the observation group were iv administered with Danshen Injection on the basis of control group, adding 20 mL of normal saline with 250 mL of normal saline to fully dilute the injection intravenously, once daily. Both groups were treated continuously for seven days. Clinical efficacy and recovery time of symptoms and signs in two groups were observed. Serum CRP, MCP-1, NLR, and amylase levels were compared before and after treatment in two groups. Results After treatment, the total effective rate of observation group was 95.74%, significantly higher than 82.98% of control group, the difference was statistically significant (P < 0.05). After treatment, the recovery time of amylase and electrolyte, disappearance time of abdominal pain and disappearance time of abdominal distension in the observation group were shorter than those in the control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of CRP, MCP-1, NLR, and serum amylase in two groups were significantly decreased (P < 0.05). After treatment, the levels of CRP, MCP-1, NLR, and amylase in observation group were significantly lower than those in control group (P < 0.05). After treatment, the whole blood high cut viscosity, plasma specific viscosity, and platelet aggregation rate in two groups were significantly decreased (P < 0.05). The whole blood high-cut viscosity, plasma specific viscosity, and platelet aggregation rate in the observation group were lower than those in the control group, with statistical significance (P < 0.05). Conclusion Danshen Injection combined with somatostatin is effective in treatment of acute pancreatitis, which can further reduce clinical symptoms, alleviate inflammatory response and improve hemorheology, with good safety.

R975