目的 探討復(fù)方丹參片聯(lián)合阿司匹林治療急性心肌梗死的臨床療效。方法 選取2019年7月—2021年6月在首都醫(yī)科大學(xué)附屬北京同仁醫(yī)院就診的急性心肌梗死患者80例，按照治療方法將患者分為對(duì)照組和觀察組，每組各40例。對(duì)照組口服阿司匹林腸溶片，首次劑量300 mg，持續(xù)劑量每日100 mg/次，1次/d。觀察組在對(duì)照組基礎(chǔ)上口服復(fù)方丹參片，3片/次，3次/d。兩組連續(xù)治療4周。觀察兩組患者的臨床療效，比較兩組治療前后的血清中內(nèi)皮素-1（ET-1）和血管緊張素Ⅱ（Ang-Ⅱ）水平、心功能指標(biāo)及血流動(dòng)力學(xué)指標(biāo)。結(jié)果 治療后，觀察組總有效率為92.5%，顯著高于對(duì)照組的75.0%，組間有明顯差異（P<0.05）。治療后，兩組的ET-1、Ang-Ⅱ水平明顯降低，內(nèi)皮依賴性血管舒張功能（FMD）明顯升高（P<0.05）；治療后，觀察組的ET-1、Ang-Ⅱ水平顯著低于對(duì)照組，F(xiàn)MD高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的左心室壓、主動(dòng)脈壓顯著升高，肺循環(huán)阻力顯著降低（P<0.05）；治療后，觀察組的左心室壓、主動(dòng)脈壓顯著高于對(duì)照組，肺循環(huán)阻力低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組的左室射血分?jǐn)?shù)（LVEF）、每搏量（SV）均顯著升高（P<0.05），且觀察組升高更明顯（P<0.05）。結(jié)論 復(fù)方丹參片能提高阿司匹林對(duì)急性心肌梗死的療效，改善患者血管內(nèi)皮功能和血流動(dòng)力學(xué)，藥物安全性良好。

Objective To investigate the clinical efficacy of Compound Danshen Tablets combined with aspirin in treatment of acute myocardial infarction. Methods Eighty patients with acute myocardial infarction who were treated in Beijing Tongren Hospital Affiliated to Capital Medical University from July 2019 to June 2021 were selected and divided into control group and observation group according to treatment methods, with 40 patients in each group. Patients in the control group were po administered with Aspirin Enteric-coated Tablets, the first dose was 300 mg, and the continuous dose was 100 mg/time, once daily, once a day. Patients in the observation group were po administered with Compound Danshen Tablets on the basis of control, three tablets/time, three times daily. Both groups were treated for 4 weeks. The clinical efficacy of the two groups was observed, and the serum levels of ET-1 and Ang-Ⅱ, cardiac function indexes, and hemodynamic indexes were compared before and after treatment. Results After treatment, the total effective rate of observation group was 92.5%, which was significantly higher than 75.0% of control group, and there was a significant difference between groups (P < 0.05). After treatment, the levels of ET-1 and Ang-Ⅱ in two groups were significantly decreased, and FMD was significantly increased (P < 0.05). After treatment, the levels of ET-1 and Ang-Ⅱ in the observation group were significantly lower than those in the control group, while FMD in the observation group was higher than those in the control group, with statistical significance (P < 0.05). After treatment, left ventricular pressure and aortic pressure in two groups were significantly increased, and pulmonary circulation resistance was significantly decreased (P < 0.05). After treatment, the left ventricular pressure and aortic pressure of the observation group were significantly higher than those of the control group, and the pulmonary circulation resistance was lower than that of the control group, with statistical significance (P < 0.05). After treatment, LVEF and SV in both groups were significantly increased (P < 0.05), and the increase was more obvious in the observation group (P < 0.05). Conclusion Compound Danshen Tablets can improve the efficacy of aspirin to acute myocardial infarction, improve vascular endothelial function and hemodynamics, and the drug safety is good.

R972