目的 探討止痛化癥膠囊聯(lián)合左氧氟沙星治療慢性盆腔炎的臨床療效。方法 選取2019年9月—2021年2月在泰州市人民醫(yī)院就診的106例慢性盆腔炎患者作為研究對象，按照治療方法將所有患者分為對照組和觀察組，各53例。對照組口服左氧氟沙星片，0.1 g/次，3次/d。觀察組在對照組基礎(chǔ)上口服止痛化癥膠囊，1.2 g/次，3次/d。連續(xù)治療2周。觀察兩組的臨床療效，比較患者治療前后的視覺模擬評分法（VAS）評分、炎性包塊的最長直徑，以及血清中人巨噬細(xì)胞趨化蛋白-1（MCP-1）、腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-6（IL-6）的水平。結(jié)果 治療后，觀察組的總有效率為94.34%，對照組為81.13%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組VAS評分均顯著降低，盆腔炎性包塊的最長直徑顯著減少（P<0.05）；且觀察組顯著低于對照組（P<0.05）。治療后，兩組的MCP-1、TNF-α、IL-6水平均顯著降低（P<0.05）；治療后，觀察組的MCP-1、TNF-α、IL-6水平顯著低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 止痛化癥膠囊聯(lián)合左氧氟沙星片治療慢性盆腔炎的療效確切，能減輕疼痛程度，縮小炎性包塊大小，降低炎癥反應(yīng)，值得臨床推廣運用。

Objective To investigate the clinical efficacy of Zhitong Huazheng Capsules combined with Levofloxacin Tablets in treatment of chronic pelvic inflammatory disease. Methods A total of 106 patients with chronic pelvic inflammatory disease treated in Taizhou People's Hospital from September 2019 to February 2021 were selected as the research subjects. According to the treatment methods, all patients were divided into control group and observation group, with 53 patients in each group. Patients in the control group were po administered with Levofloxacin Tablets, 0.1 g/time, three times daily. Patients in the observation group were po administered with Zhitong Huazheng Capsules on the basis of control group, 1.2 g/time, three times daily. The treatment lasted for two weeks. The clinical efficacy of the two groups was observed. The visual analogue scale (VAS) score, the longest diameter of inflammatory mass, and the serum levels of MCP-1, TNF-α and IL-6 were compared before and after treatment. Results After treatment, the total effective rate of the observation group was 94.34%, and that of the control group was 81.13%. The difference between the two groups was statistically significant (P < 0.05). After treatment, the VAS score and the longest diameter of pelvic inflammatory mass were significantly decreased in both groups (P < 0.05). And observation group was significantly lower than control group (P < 0.05). After treatment, the levels of MCP-1, TNF-α, and IL-6 in two groups were significantly decreased (P < 0.05). After treatment, the levels of MCP-1, TNF-α, and IL-6 in the observation group were significantly lower than those in the control group, with statistical significance (P < 0.05). Conclusion Zhitong Huazheng Capsules combined with Levofloxacin Tablet has definite efficacy in treatment of chronic pelvic inflammation, which can reduce the degree of pain, reduce the size of inflammatory mass and reduce inflammatory response, and is worthy of clinical promotion and application.

R984