為了匯總分析臨床醫(yī)生使用古方治療變應(yīng)性鼻炎的概況，為進(jìn)一步開(kāi)展古方治療鼻炎的現(xiàn)代臨床應(yīng)用及其藥效學(xué)機(jī)制研究提供參考，檢索中文學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)（CNKI）、萬(wàn)方數(shù)據(jù)庫(kù)（Wanfang Data）、維普中文期刊全文數(shù)據(jù)庫(kù)（VIP）、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)（CBM），時(shí)間為自建庫(kù)至2020年11月16日，篩選變應(yīng)性鼻炎的經(jīng)驗(yàn)介紹、病例報(bào)道類(lèi)文獻(xiàn)，整理其古方、中藥單味藥等信息，運(yùn)用SPSS Statistics 26.0、SPSS Modeler 18.0軟件進(jìn)行統(tǒng)計(jì)分析、關(guān)聯(lián)規(guī)則分析、聚類(lèi)分析、復(fù)雜網(wǎng)絡(luò)分析。共納入文獻(xiàn)305篇，涉及267位醫(yī)生或機(jī)構(gòu)的治療用藥經(jīng)驗(yàn)。使用頻率較高的古方為玉屏風(fēng)散（112）、桂枝湯（59）、麻黃細(xì)辛附子湯（49）等，功能類(lèi)別以補(bǔ)益劑、解表劑、治風(fēng)劑為主，高頻藥物為炙甘草、人參、茯苓等。關(guān)聯(lián)規(guī)則體現(xiàn)了發(fā)表補(bǔ)虛的治法。聚類(lèi)分析得到11組藥物組合。復(fù)雜網(wǎng)絡(luò)核心處方主要為桂枝湯和四君子湯。認(rèn)為中醫(yī)古方治療變應(yīng)性鼻炎多從肺脾腎入手，以補(bǔ)虛扶正為要，采用解肌發(fā)表、疏散外風(fēng)、清熱瀉火等方法治療，虛實(shí)兼顧，標(biāo)本兼治。該研究可為臨床醫(yī)生運(yùn)用中藥復(fù)方治療變應(yīng)性鼻炎提供一定參考，為中醫(yī)古方治療變應(yīng)性鼻炎的藥效學(xué)機(jī)制研究提供思路。

To summarize and analyze the application of ancient herbal formula in the treatment of allergic rhinitis by traditional Chinese medicine (TCM), in order to provide a guidance for further researches on modern clinical applications and pharmacodynamic mechanisms against allergic rhinitis, the medical experiences and case reports about allergic rhinitis were collected from the databases of CNKI, VIP, Wanfang Data and CBM. The search time was limited from database creation to November 16, 2020. Informations including related ancient herbal formula were collected. SPSS Statistics 26.0 and SPSS Modeler 18.0 software were used for statistical analysis, association rules, cluster analysis and complex network analysis. The highest usage frequency of ancient herbal formula was Yupingfeng San (112), followed by Guizhi Decoction (59), Mahuang Fuzi Xixin Decoction (49), and etc. Supplementing formula was the top one by classification of functions, followed by superficies-resolving formula, and formula for wind disorder. The highest usage frequency of TCM was baked licorice, ginseng, tuckahoe, and etc. Association rules embodied the treatment methods ofrelieving superficies and supplementing. In the cluster analysis, eleven groups of TCM combinations were obtained. The core prescription of complex network mainly consisted of Guizhi Decoction and Sijunzi Decoction. To treat allergic rhinitis with ancient prescriptions of TCM was mainly focused the lungs, spleen and kidney, so as to restore tonify deficiency. According to syndrome differentiation, there were many therapeutic methods used to treat allergic rhinitis such as releasing muscle, evacuating wind, clearing heat and reducing fire and so on, in order to treat both deficiency and excess, address both the symptoms and root causes. The paper may provide a guidance for clinicians in the treatment of allergic rhinitis, as well as offer a reference for pharmacodynamics mechanism study of TCM ancient prescriptions against allergic rhinitis.

R287.7

國(guó)家自然科學(xué)基金資助項(xiàng)目（81603513）；廣東省自然科學(xué)基金資助項(xiàng)目（2021A1515011485）；吉林大學(xué)珠海學(xué)院創(chuàng)新強(qiáng)校工程項(xiàng)目國(guó)外引進(jìn)博士科技創(chuàng)新團(tuán)隊(duì)項(xiàng)目（2018KCTD03）